INT107302

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 8.52
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fasl) extracellular space (Fasl) extracellular region (Fasl)
cytoplasmic membrane-bounded vesicle (Fasl) plasma membrane (Fasl) lysosome (Fasl)
Anatomy Link Frequency
respiratory 3
blood 2
keratinocytes 2
synovium 2
T cells 2
Fasl (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 143 99.44 Very High Very High Very High
Inflammation 99 96.20 Very High Very High Very High
Paracetamol 22 93.20 High High
anticonvulsant 1 87.60 High High
cytokine 28 80.32 Quite High
Pain 2 67.20 Quite High
chemokine 10 64.20 Quite High
Inflammatory response 6 62.00 Quite High
metalloproteinase 20 59.92 Quite High
withdrawal 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 372 100.00 Very High Very High Very High
Ulcers 2 100.00 Very High Very High Very High
Rheumatoid Arthritis 143 99.44 Very High Very High Very High
Toxoplasmosis 12 98.04 Very High Very High Very High
Infection 56 97.64 Very High Very High Very High
Necrosis 8 97.36 Very High Very High Very High
INFLAMMATION 108 96.20 Very High Very High Very High
Targeted Disruption 12 95.42 Very High Very High Very High
Injury 38 94.04 High High
Chorioretinitis 2 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The protection was associated with decreased FasL-expressing cells, cytotoxicity against hepatocytes, and respiratory burst in hepatic leukocytes.
Negative_regulation (decreased) of Gene_expression (expressing) of FasL in respiratory
1) Confidence 0.42 Published 2006 Journal Hepatology Section Abstract Doc Link 16729305 Disease Relevance 0.81 Pain Relevance 0.81
In contrast, reduced expression of the apoptosis regulatory proteins FasL and Bad was found after a single administration of methadone.
Negative_regulation (reduced) of Gene_expression (expression) of FasL
2) Confidence 0.41 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17384938 Disease Relevance 0.07 Pain Relevance 0
The transgenic FasL mRNA was highly expressed on days 2 to 10 and obviously decreased on day 20 after virus injection (Fig. 2, lanes 2–6), which suggests that repeated administration of FasL gene transfer would be necessary to maintain a high level of FasL transgene expression in vivo.
Negative_regulation (level) of Gene_expression (expression) of FasL associated with targeted disruption
3) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 0.82 Pain Relevance 0.17
We determined Fas and FasL protein expression in engrafted RA synovium by immunohistochemistry using polyclonal anti-Fas and anti-FasL antibodies.
Spec (determined) Negative_regulation (determined) of Spec (determined) Gene_expression (expression) of FasL protein in synovium associated with rheumatoid arthritis
4) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297566 Disease Relevance 1.05 Pain Relevance 0.32
Fas-L expression of macrophages and T cells may induce apoptosis and contribute to ulcer formation in Fas-expressing keratinocytes during L. major infection.


Negative_regulation (ulcer) of Gene_expression (expression) of Fas-L in keratinocytes associated with ulcers, apoptosis and infection
5) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.47 Pain Relevance 0
To test this, lpr mice and gld mice which have defective Fas and FasL expressions respectively, were used [32,47].
Negative_regulation (defective) of Gene_expression (expressions) of FasL
6) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.87 Pain Relevance 0.14
The TCAH-induced decrease in apoptosis correlated with the decreased expression of FasL, but not Fas, on the surface of the CD4+ T cells.
Negative_regulation (decreased) of Gene_expression (expression) of FasL in T cells associated with apoptosis
7) Confidence 0.26 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 1.26 Pain Relevance 0.08
The protection was associated with decreased FasL-expressing cells, cytotoxicity against hepatocytes, and respiratory burst in hepatic leukocytes.
Negative_regulation (decreased) of in hepatocytes Gene_expression (expressing) of FasL in respiratory
8) Confidence 0.14 Published 2006 Journal Hepatology Section Abstract Doc Link 16729305 Disease Relevance 0.81 Pain Relevance 0.81
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Spec (determined) Negative_regulation (determined) of Gene_expression (expression) of FasL in blood
9) Confidence 0.06 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23

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