INT107307

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 18.16
Pain Relevance 9.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
T-cell 2
Mouse 1
SVR 1
mononuclear cell 1
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 657 100.00 Very High Very High Very High
Paracetamol 496 100.00 Very High Very High Very High
Neuritis 11 99.06 Very High Very High Very High
Multiple sclerosis 73 97.60 Very High Very High Very High
rheumatoid arthritis 286 96.88 Very High Very High Very High
chemokine 92 96.48 Very High Very High Very High
Infliximab 29 96.20 Very High Very High Very High
depression 18 95.68 Very High Very High Very High
Sciatic nerve 1 94.28 High High
Crohn's disease 54 93.64 High High
Disease Link Frequency Relevance Heat
Cancer 430 99.76 Very High Very High Very High
Asthma 52 99.72 Very High Very High Very High
Psoriasis 121 99.52 Very High Very High Very High
Necrosis 39 99.40 Very High Very High Very High
Experimental Autoimmune Neuritis 10 99.06 Very High Very High Very High
Hepatotoxicity 31 98.08 Very High Very High Very High
Hypersensitivity 46 98.00 Very High Very High Very High
Multiple Sclerosis 58 97.60 Very High Very High Very High
Disease 312 96.88 Very High Very High Very High
Rheumatoid Arthritis 287 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this investigation, mRNA expression of IFN-?
Transcription (expression) of IFN
1) Confidence 0.52 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1402316 Disease Relevance 0.83 Pain Relevance 0.14
To study the potential role of cytokines in context with cytokine autoantibodies (Aabs) in EAN, we used in situ hybridization to detect mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-4, IL-10, and transforming growth factor (TGF)-beta in lymph node mononuclear cell (MNC) and in sciatic nerve sections, as well as ELISA for detection of their autoantibodies in sera and cerebrospinal fluid (CSF) over the course of EAN.
Transcription (expression) of IFN in mononuclear cell associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
2) Confidence 0.52 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.12 Pain Relevance 1.00
mRNA and additional reduced expression was seen for IFN?
Transcription (seen) of IFN
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 1.04 Pain Relevance 0.54
It is well understood that IFN-?
Transcription (understood) of IFN
4) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.72 Pain Relevance 0.53
A study in which treatment with interferon was initiated one year after the onset of symptoms achieved a disappointing 40% SVR rate [3].
Transcription (initiated) of interferon in SVR
5) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605267 Disease Relevance 0.63 Pain Relevance 0
By contrast, we never detected a raise in IFN-?
Transcription (detected) of IFN
6) Confidence 0.26 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2950153 Disease Relevance 0.28 Pain Relevance 0.28
IL-18, initially described as an IFN-?
Transcription (described) of IFN
7) Confidence 0.24 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.38 Pain Relevance 0.35
RIG-1 is activated by the binding of viral RNA, which enables RIG-1 to bind to IFN promoter stimulator 1(IPS-1) and trigger a signaling cascade that results in IFN transcription.
Transcription (transcription) of IFN
8) Confidence 0.16 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.49 Pain Relevance 0.14
Likewise, clinical efficacy of cyclosporine is associated with decreased serum levels of IFN-?
Transcription (levels) of IFN
9) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.23 Pain Relevance 0.30
Recently, it was found that miltefosine enhanced IFN-?
Transcription (found) of IFN
10) Confidence 0.14 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.26 Pain Relevance 0.05
STAT1H tumor cells also demonstrate resistance to IFN-gamma (IFN?)
Transcription (demonstrate) of IFN associated with cancer
11) Confidence 0.11 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2688034 Disease Relevance 0.93 Pain Relevance 0
have been detected in the bronchoalveolar lavage (BAL) fluid of patients with stable asthma, whereas the levels of mRNA for IFN-?
Transcription (levels) of IFN associated with asthma
12) Confidence 0.09 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.99 Pain Relevance 0.31
In the presence of high levels of IFN-?
Transcription (presence) of IFN
13) Confidence 0.08 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.45 Pain Relevance 0.03
On the other hand, there were no changes in mRNA expression levels from splenic cells for IFN-?
Transcription (levels) of IFN
14) Confidence 0.07 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.92 Pain Relevance 0.25
Limited gene profiling of CFSElo HA-specific T cells from A20HA bearing mice demonstrated less mRNA for IL-2, CD40L, t-bet, and IFN-?
Transcription (demonstrated) of IFN in T cells
15) Confidence 0.06 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.58 Pain Relevance 0
transcriptional response was significant in the context of the magnitude of the IFN- ?
Transcription (magnitude) of IFN
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.17 Pain Relevance 0.90
As we observe in Table1, this broad effect coincides with an overall global dampening of transcription in IFN-?
Transcription (transcription) of IFN
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.10 Pain Relevance 0.52
Total mRNA isolated from murine hepatic tissue in mice treated with APAP alone, IFN-?
Transcription (isolated) of IFN associated with paracetamol
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.24 Pain Relevance 0.74
These time points were consistent with previously published studies on mRNA expression following APAP or IFN-?
Transcription (expression) of IFN associated with paracetamol
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882945 Disease Relevance 0.37 Pain Relevance 0.61
In the present study, we studied the effect of TNF blockade on the transcription of type I IFN response genes.
Transcription (transcription) of IFN
20) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.58 Pain Relevance 0.25

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