INT107332

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Context Info
Confidence 0.19
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sigmar1) nuclear envelope (Sigmar1) lipid particle (Sigmar1)
endoplasmic reticulum (Sigmar1) plasma membrane (Sigmar1) nucleus (Sigmar1)
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 100.00 Very High Very High Very High
Dopamine 12 99.68 Very High Very High Very High
fortral 6 99.48 Very High Very High Very High
Kinase C 14 99.20 Very High Very High Very High
antagonist 2 88.52 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested several inhibitors of PKC isozymes, as well as a phospholipase C inhibitor for their effects on sigma1 receptor agonist-mediated regulation of [3H]dopamine release.
Negative_regulation (inhibitor) of Regulation (regulation) of sigma1 receptor associated with dopamine, kinase c and agonist
1) Confidence 0.19 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490613 Disease Relevance 0 Pain Relevance 0.90
Although none of the inhibitors tested affected the ability of NMDA to stimulate [3H]dopamine release, they all abolished regulation by the sigma1 receptor agonist (+)-pentazocine in a concentration-related manner.
Negative_regulation (abolished) of Regulation (regulation) of sigma1 receptor associated with fortral, dopamine and agonist
2) Confidence 0.19 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12490613 Disease Relevance 0 Pain Relevance 0.96

General Comments

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