INT107340

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.64
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 99.04 Very High Very High Very High
Central nervous system 14 82.64 Quite High
Dopamine 1 82.20 Quite High
nMDA receptor 1 81.64 Quite High
Nicotine 1 74.80 Quite High
Eae 2 32.48 Quite Low
Hippocampus 10 19.04 Low Low
Pyramidal cell 2 6.68 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 11 99.72 Very High Very High Very High
INFLAMMATION 22 98.84 Very High Very High Very High
Disease 104 97.80 Very High Very High Very High
Aging 8 89.76 High High
Cognitive Disorder 11 85.96 High High
Targeted Disruption 4 85.48 High High
Amyloid Plaque 10 84.40 Quite High
Death 9 81.56 Quite High
Neurodegenerative Disease 11 79.64 Quite High
Dementia 17 76.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitors of tau protein phosphorylation and activators of phosphates could be that of anti-tau protein phosphorylation.
Negative_regulation (inhibitors) of Phosphorylation (phosphorylation) of tau
1) Confidence 0.57 Published 2002 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 12491771 Disease Relevance 0.56 Pain Relevance 0.21
The modern strategy of treatment such as acetylcholine esterase inhibitors, neuroprotectors, neurotrophic factors, inhibitors of beta- and gamma-secretase, beta-amyloid aggregation inhibitors, beta-amyloid degradation stimulators, beta-amyloid vaccination, inhibitors of tau protein phosphorylation, estrogens, nonsteroid anti-inflammatory drugs is discussed.
Negative_regulation (inhibitors) of Phosphorylation (phosphorylation) of tau associated with inflammation, alzheimer's dementia and cinod
2) Confidence 0.57 Published 2003 Journal Lik. Sprava Section Abstract Doc Link 14723127 Disease Relevance 1.19 Pain Relevance 0.10
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Negative_regulation (Impaired) of Phosphorylation (hyperphosphorylation) of Tau
3) Confidence 0.41 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.89 Pain Relevance 0.04

General Comments

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