INT107341

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Context Info
Confidence 0.80
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 14.00
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPT) cell death (MAPT) plasma membrane (MAPT)
cytoskeleton (MAPT) enzyme binding (MAPT) cytoplasm (MAPT)
Anatomy Link Frequency
neuronal 1
Brain 1
PSP 1
prefrontal 1
hippocampus 1
MAPT (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 99.04 Very High Very High Very High
Hippocampus 92 97.16 Very High Very High Very High
Pain 11 93.32 High High
Pyramidal cell 18 93.28 High High
Neurotransmitter 27 91.32 High High
Eae 23 88.76 High High
Dopamine 3 81.64 Quite High
nMDA receptor 3 81.08 Quite High
Central nervous system 137 80.72 Quite High
Nicotine 3 74.24 Quite High
Disease Link Frequency Relevance Heat
Disease 990 100.00 Very High Very High Very High
Neurodegenerative Disease 108 100.00 Very High Very High Very High
Tauopathy 18 100.00 Very High Very High Very High
Parkinson's Disease 12 100.00 Very High Very High Very High
Frontotemporal Dementia 3 100.00 Very High Very High Very High
Supranuclear Palsy 15 99.76 Very High Very High Very High
Alzheimer's Dementia 65 99.48 Very High Very High Very High
Congenital Anomalies 54 99.24 Very High Very High Very High
Targeted Disruption 61 99.16 Very High Very High Very High
Drug Induced Neurotoxicity 12 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitors of tau protein phosphorylation and activators of phosphates could be that of anti-tau protein phosphorylation.
Phosphorylation (phosphorylation) of tau
1) Confidence 0.80 Published 2002 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 12491771 Disease Relevance 0.49 Pain Relevance 0.20
Tau is normally phosphorylated by GSK-3?
Phosphorylation (phosphorylated) of Tau
2) Confidence 0.80 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.04 Pain Relevance 0.04
and the phosphorylation of the Tau protein, the two hallmarks of AD.


Phosphorylation (phosphorylation) of Tau associated with disease
3) Confidence 0.80 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.43 Pain Relevance 0.06
42 protein, neurofibrillary tangles composed of hyperphosphorylated Tau protein, and the loss of a significant fraction of the neurons in the hippocampus, prefrontal and entorhinal cortex [15]–[19].
Phosphorylation (hyperphosphorylated) of Tau in hippocampus associated with hippocampus
4) Confidence 0.80 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597734 Disease Relevance 0.88 Pain Relevance 0.05
Impaired insulin/IGF1 signalling results in the hyperphosphorylation of Tau due to reduced activation of PI3K/AKT and increased levels of GSK-3?
Phosphorylation (hyperphosphorylation) of Tau
5) Confidence 0.80 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.88 Pain Relevance 0.04
contributes to the hyper-phosphorylation of Tau [78] and regulates the production of the APP derivative A?
Phosphorylation (phosphorylation) of Tau
6) Confidence 0.80 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.27 Pain Relevance 0.05
The modern strategy of treatment such as acetylcholine esterase inhibitors, neuroprotectors, neurotrophic factors, inhibitors of beta- and gamma-secretase, beta-amyloid aggregation inhibitors, beta-amyloid degradation stimulators, beta-amyloid vaccination, inhibitors of tau protein phosphorylation, estrogens, nonsteroid anti-inflammatory drugs is discussed.
Phosphorylation (phosphorylation) of tau associated with inflammation, alzheimer's dementia and cinod
7) Confidence 0.80 Published 2003 Journal Lik. Sprava Section Abstract Doc Link 14723127 Disease Relevance 1.19 Pain Relevance 0.10
There are two different hypotheses that neurotoxicity of aggregated amyloid beta protein(A beta) and hyperphosphorylation of tau protein are the causes of AD.
Phosphorylation (hyperphosphorylation) of tau associated with drug induced neurotoxicity and alzheimer's dementia
8) Confidence 0.80 Published 2002 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 12491771 Disease Relevance 0.88 Pain Relevance 0.06
The inhibitors of tau protein phosphorylation and activators of phosphates could be that of anti-tau protein phosphorylation.
Phosphorylation (phosphorylation) of tau
9) Confidence 0.80 Published 2002 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 12491771 Disease Relevance 0.50 Pain Relevance 0.21
Instead, the hyperphosphorylated Tau proteins bind to each other and tie themselves into “knots” known as NFTs [36].
Phosphorylation (hyperphosphorylated) of Tau
10) Confidence 0.80 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.39 Pain Relevance 0.11
However, in AD the Tau proteins become hyperphosphorylated and lose the ability to bind to microtubules.
Phosphorylation (hyperphosphorylated) of Tau associated with disease
11) Confidence 0.79 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.49 Pain Relevance 0.12
contributes to the hyper-phosphorylation of Tau [78] and regulates the production of the APP derivative A?
Phosphorylation (phosphorylation) of Tau
12) Confidence 0.79 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.27 Pain Relevance 0.05
ERK, mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 5 (CDK-5) are important for the physiological phosphorylation of Tau protein, both of which are activated by insulin/IGF1 receptor.
Phosphorylation (phosphorylation) of Tau
13) Confidence 0.61 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.09 Pain Relevance 0.13
Hyper-phosphorylated Tau fails to be transported into axons and instead accumulates and aggregates in neuronal perikarya, where it promotes oxidative stress that can cause cell death mediated by apoptosis, mitochondrial dysfunction or necrosis.
Phosphorylation (phosphorylated) of Tau in neuronal associated with parkinson's disease, stress, necrosis, apoptosis and death
14) Confidence 0.61 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.12 Pain Relevance 0.09
NFT are mainly composed of hyperphosphorylated microtubule-associated protein tau.
Phosphorylation (hyperphosphorylated) of microtubule-associated protein tau
15) Confidence 0.61 Published 2009 Journal Neuroscience Section Abstract Doc Link 19362124 Disease Relevance 0.93 Pain Relevance 0.12
Nowadays several protein kinases have been implicated in the phosphorylation of tau, including glycogen synthase kinase 3 beta (GSK3beta), MAP kinase, protein kinase A and cyclin-dependent kinase 5 (Cdk5).
Phosphorylation (phosphorylation) of tau
16) Confidence 0.61 Published 2009 Journal Neuroscience Section Abstract Doc Link 19362124 Disease Relevance 0.91 Pain Relevance 0.12
Brain homogenate from tau knockout mouse was used as a negative control for phosphorylated Tau protein assays.
Phosphorylation (phosphorylated) of Tau in Brain associated with targeted disruption
17) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956689 Disease Relevance 0.10 Pain Relevance 0
42 protein, neurofibrillary tangles composed of hyperphosphorylated Tau protein, and the loss of a significant fraction of the neurons in the hippocampus, prefrontal and entorhinal cortex [15]–[19].
Phosphorylation (hyperphosphorylated) of Tau in prefrontal associated with hippocampus
18) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597734 Disease Relevance 0.88 Pain Relevance 0.05
Paired helical filaments and the hyperphosphorylation of tau are two of the most recognized molecular characteristics in Alzheimer's disease (AD) and several other neurodegenerative tauopathies, for example, frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and progressive supranuclear palsy (PSP) [28].
Phosphorylation (hyperphosphorylation) of FTDP-17 in PSP associated with parkinson's disease, tauopathy, supranuclear palsy, frontotemporal dementia, neurodegenerative disease and disease
19) Confidence 0.17 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604894 Disease Relevance 1.25 Pain Relevance 0.03

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