INT107381

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.32
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAPPA) peptidase activity (PAPPA) extracellular region (PAPPA)
Anatomy Link Frequency
shoulder 2
coronary artery 2
plaques 2
PAPPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 50 99.72 Very High Very High Very High
Inflammation 30 95.80 Very High Very High Very High
cytokine 5 77.44 Quite High
ischemia 29 24.96 Low Low
Bioavailability 2 12.88 Low Low
metalloproteinase 11 5.96 Low Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 14 99.72 Very High Very High Very High
Acute Coronary Syndrome 107 99.44 Very High Very High Very High
Atherosclerotic Plaque 15 98.88 Very High Very High Very High
Coronary Stenosis 1 98.32 Very High Very High Very High
Myocardial Infarction 56 97.24 Very High Very High Very High
INFLAMMATION 35 95.80 Very High Very High Very High
Angina 35 82.24 Quite High
Cardiovascular Disease 4 78.12 Quite High
Stable Angina Pectoris 1 75.00 Quite High
Atherosclerosis 19 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAPP-A levels and PAPP-A/pro-MBP ratio are increased in chronic stable angina (CSA) patients with complex coronary artery stenoses.
Positive_regulation (increased) of Gene_expression (levels) of PAPP-A in coronary artery associated with coronary stenosis and angina
1) Confidence 0.49 Published 2008 Journal Clin. Chim. Acta Section Abstract Doc Link 18267116 Disease Relevance 0.47 Pain Relevance 0.43
Bayes-Genis et al. found abundant PAPP-A expression in unstable plaques but not in stable plaques from patients died of sudden cardiac death, mostly in the inflammatory shoulder region.
Positive_regulation (abundant) of Gene_expression (expression) of PAPP-A in shoulder associated with inflammation and myocardial infarction
2) Confidence 0.49 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.79 Pain Relevance 0.13
CONCLUSIONS: The data are consistent with the conclusion that expression of PAPP-A is enhanced in patients with biochemical evidence of acute coronary syndrome and suggest strongly that demonstration of PAPP-A association with other cardiac markers might be influenced by their relative release dynamics (timing and duration).
Positive_regulation (enhanced) of Gene_expression (expression) of PAPP-A
3) Confidence 0.45 Published 2002 Journal Clin. Biochem. Section Body Doc Link 12493581 Disease Relevance 0.06 Pain Relevance 0
Moreover, increased serum levels of PAPP-A may reflect instability of atherosclerotic plaques.54
Positive_regulation (increased) of Gene_expression (levels) of PAPP-A in plaques associated with atherosclerotic plaque
4) Confidence 0.45 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.00 Pain Relevance 0.29

General Comments

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