INT107390

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 6.00
Pain Relevance 4.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
liver 1
soma 1
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 41 100.00 Very High Very High Very High
Glutamate receptor 36 100.00 Very High Very High Very High
Analgesic 3 99.76 Very High Very High Very High
Action potential 44 99.16 Very High Very High Very High
Paracetamol 2 97.76 Very High Very High Very High
amygdala 26 93.64 High High
Nucleus accumbens 16 92.52 High High
Inflammation 6 92.40 High High
Dopamine 24 90.44 High High
Pain management 1 89.04 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 11 99.36 Very High Very High Very High
Targeted Disruption 163 98.48 Very High Very High Very High
Nociception 12 98.10 Very High Very High Very High
Hepatotoxicity 4 97.20 Very High Very High Very High
Congenital Anomalies 4 97.16 Very High Very High Very High
Injury 5 97.04 Very High Very High Very High
Syndrome 48 93.12 High High
Hypoxia 2 92.96 High High
Death 2 92.64 High High
INFLAMMATION 6 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent paper identified a role for the mGluR5 receptor in Pavlovian to instrumental transfer; that is, when mGluR5 was blocked during Pavlovian conditioning training, the cue later failed to serve as a reinforcer in an operant test of conditioned reinforcement [32].
Negative_regulation (blocked) of mGluR5
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.23 Pain Relevance 0.24
We examined the ability of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective antagonist of the type 5 metabotropic glutamate receptor (mGluR5), to reduce the rewarding effects of various drugs of abuse in the conditioned place preference (CPP) paradigm.
Negative_regulation (antagonist) of mGluR5 associated with glutamate receptor and antagonist
2) Confidence 0.42 Published 2003 Journal Synapse Section Abstract Doc Link 12494407 Disease Relevance 0 Pain Relevance 0.37
We also found no difference in rectal temperature between genotypes (Table 1), suggesting that there are no gross metabolic disturbances induced by disruption of grm5.
Negative_regulation (disruption) of grm5
3) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.46 Pain Relevance 0.03
Under the same conditions, separate mGluR5 KO mice were able to acquire operant responding for food, indicating that the loss of mGluR5 did not have non-specific effects on operant learning.
Negative_regulation (loss) of mGluR5 associated with targeted disruption
4) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.60 Pain Relevance 0.40
It was predicted that these measures would also be influenced by mGluR5 disruption, as studies using pharmacological or genetic blockade of mGluR5 have revealed a role for mGluR5 in these phenotypes [2]–[4], [7], [25].
Negative_regulation (blockade) of mGluR5
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.25 Pain Relevance 0.08
DHPG-induced peripheral hypersensitivity is reduced via pharmacological blockade of mGluR5 or genetic disruption of mGluR5.
Negative_regulation (disruption) of mGluR5 associated with hypersensitivity
6) Confidence 0.20 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 1.00 Pain Relevance 0.65
DHPG-induced peripheral hypersensitivity is reduced via pharmacological blockade of mGluR5 or genetic disruption of mGluR5.
Negative_regulation (blockade) of mGluR5 associated with hypersensitivity
7) Confidence 0.12 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 1.00 Pain Relevance 0.64
The lack of effect with application to the dendrites does not necessarily imply the absence of group I mGluRs, as backpropagating action potentials could have a different effect from action potentials in the soma (see Discussion).
Negative_regulation (absence) of mGluRs in soma associated with action potential
8) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.25
Block of the medium ADP by micromolar Ni2+ and the strong reduction of mGluR-mediated modulation of the post-burst potential in Cav2.3 knockout mice suggest that activation of R-type VGCCs are required for conversion of the medium AHP to a medium ADP [31]–[33].
Negative_regulation (reduction) of mGluR associated with targeted disruption
9) Confidence 0.05 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.10 Pain Relevance 0.18
Lithium was found to reduce mGluR-activated translation and reversed phenotypes in the dfxr mutant fly and fmr1 knockout mouse.
Negative_regulation (reduce) of mGluR associated with targeted disruption
10) Confidence 0.02 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2958860 Disease Relevance 0.75 Pain Relevance 0.19
In the present study, effects of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective mGlu5 receptor antagonist, were examined in a wide variety of rodent nociceptive and hypersensitivity models in order to fully characterize the potential analgesic profile of mGlu5 receptor blockade.
Negative_regulation (blockade) of mGlu5 associated with nociception, analgesic, antagonist and hypersensitivity
11) Confidence 0.02 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15588730 Disease Relevance 0.96 Pain Relevance 0.60
In conclusion, blockade of mGluR1 showed antipsychotic-like effects without impairing motor functions, whereas blockade of mGluR5 and activation of mGluR2/3 did not display such activities.
Negative_regulation (blockade) of mGluR5
12) Confidence 0.01 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18487514 Disease Relevance 0.27 Pain Relevance 0.50
Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice.
Negative_regulation (blockade) of mGlu5 associated with paracetamol, glutamate receptor and hepatotoxicity
13) Confidence 0.00 Published 2003 Journal J. Hepatol. Section Title Doc Link 12547406 Disease Relevance 0.28 Pain Relevance 0.29
CONCLUSIONS: We conclude that pharmacological blockade of mGlu5 receptors might represent a novel target for the treatment of drug-induced liver damage.


Negative_regulation (blockade) of mGlu5 in liver
14) Confidence 0.00 Published 2003 Journal J. Hepatol. Section Body Doc Link 12547406 Disease Relevance 0.11 Pain Relevance 0

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