INT107392

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.01
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2, PTGS1) endoplasmic reticulum (PTGS2, PTGS1) cytoplasm (PTGS2, PTGS1)
lipid binding (PTGS2, PTGS1) oxidoreductase activity (PTGS2, PTGS1) nucleus (PTGS2, PTGS1)
PTGS2 (Homo sapiens)
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 75.00 Quite High
COX-2 inhibitor 3 75.00 Quite High
Inflammation 3 65.36 Quite High
metalloproteinase 1 55.68 Quite High
cytokine 1 50.24 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 9 97.48 Very High Very High Very High
Colon Cancer 4 96.76 Very High Very High Very High
Familial Adenomatous Polyposis 2 82.48 Quite High
Colorectal Cancer 6 75.00 Quite High
INFLAMMATION 2 65.36 Quite High
Apoptosis 1 64.80 Quite High
Metastasis 1 58.80 Quite High
Adenoma 2 25.00 Low Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cyclooxygenase-2 (COX-2), an inducible prostaglandin G/H synthase, is overexpressed in pre-neoplastic tissues and several human cancers including colorectal cancer.
Cyclooxygenase-2 Positive_regulation (inducible) of prostaglandin G/H synthase associated with cancer and colon cancer
1) Confidence 0.31 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353307 Disease Relevance 0.48 Pain Relevance 0.09
Cyclooxygenase-2 (COX-2), the inducible cyclooxygenase isozyme involved in the conversion of arachidonic acid (AA) to biologically active prostanoids, has become the subject of intense interest during the last few years.
Cyclooxygenase-2 Positive_regulation (inducible) of cyclooxygenase isozyme
2) Confidence 0.15 Published 2002 Journal In Vivo Section Abstract Doc Link 12494894 Disease Relevance 0.53 Pain Relevance 0.17

General Comments

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