INT107400

Context Info Confidence 0.28 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.95 Pain Relevance 1.00

Anatomy Link Frequency Articular 1 blood 1 B-cell 1 Das (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 94.48 qutenza 8 94.04 Inflammation 27 93.20 cytokine 8 87.56 rheumatoid arthritis 95 85.88 antagonist 3 75.00 cINOD 4 57.24 Pain 8 53.92 Inflammatory marker 2 52.08 Infliximab 108 50.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 106 100.00 Pressure And Volume Under Development 3 98.88 INFLAMMATION 27 93.20 Disease 161 91.84 Rheumatoid Arthritis 99 85.88 Arthritis 9 77.60 Pain 4 53.92 Colon Cancer 3 44.80 Hemorrhage 4 43.88 Toxic Megacolon 2 42.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, we examined the effect of lafutidine on gastric mucosal blood flow (GMBF) and duodenal HCO3- secretion (DAS) under basal and acid-stimulated conditions in rats.

Localization (secretion) of DAS in blood

1) Confidence 0.28 Published 2002 Journal Dig. Dis. Sci. Section Abstract Doc Link 12498288 Disease Relevance 0 Pain Relevance 0.30

The DAS was calculated using a 44 joint count for swelling (swollen joint count, SJC), a 53 joint count graded for tenderness (tender joint count, TJC), counted in 26 joint units (Ritchie Articular Index, RAI), general health on a Visual Analogue Scale (VAS) of 100 mm, and the value for ESR measured by the Westergren method[16].

Localization (calculated) of DAS in Articular associated with pressure and volume under development

2) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911884 Disease Relevance 0.75 Pain Relevance 0.21

An advantage of the SDAI and CDAI over the DAS is that they do not require a complex formula or a calculator and can be used more readily in clinical practice.

Localization (advantage) of DAS

3) Confidence 0.07 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2927687 Disease Relevance 0.74 Pain Relevance 0.14

Also, autoantibodies directed against endogenous proteins such as tropomyosins are secreted in the serum of UC patients, corroborating the role of humoral, B-cell-mediated immunity in UC (Das et al. 1993).

Localization (secreted) of Das in B-cell associated with inflammatory bowel disease

4) Confidence 0.03 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012439 Disease Relevance 1.46 Pain Relevance 0.34

General Comments

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