INT10744

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Context Info
Confidence 0.66
First Reported 1984
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 3.95
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PIF1) helicase activity (PIF1) DNA binding (PIF1)
Anatomy Link Frequency
capillary 2
tail 1
neural 1
PIF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 99.88 Very High Very High Very High
Calcitonin gene-related peptide 6 99.76 Very High Very High Very High
analgesia 18 99.32 Very High Very High Very High
qutenza 8 98.80 Very High Very High Very High
anesthesia 18 94.76 High High
substance P 12 90.24 High High
epidural 8 81.04 Quite High
Neuropeptide 4 75.44 Quite High
cerebral cortex 8 43.16 Quite Low
imagery 4 11.80 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 99.88 Very High Very High Very High
Burns 1 99.84 Very High Very High Very High
Pressure And Volume Under Development 22 99.40 Very High Very High Very High
Peripheral Arterial Disease 12 99.40 Very High Very High Very High
Increased Venous Pressure Under Development 2 79.40 Quite High
Adhesions 2 78.04 Quite High
Neurogenic Inflammation 5 75.00 Quite High
Blister 2 67.20 Quite High
Unconsciousness 16 5.00 Very Low Very Low Very Low
Coma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Measurements were performed after circulatory arrest, since the oedema formation associated with acute inflammation will increase Pif in a positive direction, which may potentially underestimate the increased negativity of Pif.
Positive_regulation (increase) of Pif associated with pressure and volume under development and inflammation
1) Confidence 0.66 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9401595 Disease Relevance 0.44 Pain Relevance 0.53
Interstitial fluid pressure (Pif) was studied, since increased negativity of Pif contributes to edema formation in this situation. alpha-Trinositol was used because it inhibits edema formation, capillary leakage, and increased negativity of Pif in burn-injured skin.
Positive_regulation (increased) of Pif in capillary associated with pressure and volume under development and burns
2) Confidence 0.49 Published 1994 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 7921464 Disease Relevance 0.85 Pain Relevance 0.23
Intravenous injection of capsaicin (65.0 nmol) and calcitonin gene-related peptide (1.3 nmol) increased the negativity of Pif to -4.0 +/- 1.2 mmHg (n = 8) (P < 0.01) and -4.7 +/- 2.0 mmHg (n = 9) (P < 0.01), respectively.
Positive_regulation (increased) of Pif associated with qutenza and calcitonin gene-related peptide
3) Confidence 0.47 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9401595 Disease Relevance 0.36 Pain Relevance 0.68
This procedure prevents the vascular phenomena of increased fluid and protein flux leading to edema formation, which in turn can increase Pif and therefore potentially mask an increased negativity of Pif.
Positive_regulation (increased) of Pif associated with pressure and volume under development
4) Confidence 0.45 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1516168 Disease Relevance 0.46 Pain Relevance 0.13
The subcutaneous interstitial tissue could be less expanded postoperatively in the TEA-group, also reflected by a lower increase in Pif.
Positive_regulation (increase) of Pif associated with analgesia
5) Confidence 0.40 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2644753 Disease Relevance 0.06 Pain Relevance 0.77
At the end of extracorporeal circulation Pif increased to a minor degree in the TEA-group and remained significantly lower than in controls from 3 to 24 h postoperatively.
Positive_regulation (increased) of Pif associated with analgesia
6) Confidence 0.40 Published 1989 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 2644753 Disease Relevance 0.07 Pain Relevance 1.02
This procedure prevents the vascular phenomena of increased fluid and protein flux leading to edema formation, which in turn can increase Pif and therefore potentially mask an increased negativity of Pif.
Positive_regulation (increase) of Pif associated with pressure and volume under development
7) Confidence 0.37 Published 1992 Journal Circ. Res. Section Abstract Doc Link 1516168 Disease Relevance 0.47 Pain Relevance 0.13
Venous stasis (cuff pressure 14.7 mmHg) increased PIF and Pv by 3.5 and 9 mmHg, respectively, while tail volume increased by 0.4 to 1.2%.
Positive_regulation (increased) of PIF in tail
8) Confidence 0.34 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6742216 Disease Relevance 0.43 Pain Relevance 0.07
PIF increased to 15 mmHg, in parallel with Pv.
Positive_regulation (increased) of PIF
9) Confidence 0.34 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6742216 Disease Relevance 0.43 Pain Relevance 0.08
Subcutaneous tissue is compressed between the expanding vessels and the tight skin, and PIF increases almost sufficiently to prevent a rise in net capillary filtration pressure.
Positive_regulation (increases) of PIF in capillary
10) Confidence 0.34 Published 1984 Journal Am. J. Physiol. Section Abstract Doc Link 6742216 Disease Relevance 0.39 Pain Relevance 0.06
appear to require both functional specialization and functional integration.
Positive_regulation (require) of integration
11) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0
As shown by computer simulations, systems of neural elements whose connectivity jointly satisfies the requirements for functional specialization and for functional integration are well suited to integrating information.
Positive_regulation (requirements) of integration in neural
12) Confidence 0.03 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC543470 Disease Relevance 0 Pain Relevance 0

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