INT107448

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.33
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Anatomy Link Frequency
granulocyte 1
SH2 1
T-cells 1
Jak2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 5 99.58 Very High Very High Very High
Opioid 4 99.46 Very High Very High Very High
Potency 53 99.42 Very High Very High Very High
cerebral cortex 3 92.00 High High
ischemia 14 88.84 High High
cva 1 88.24 High High
Pain 4 86.24 High High
Angina 6 85.48 High High
agonist 78 85.04 High High
rheumatoid arthritis 44 84.12 Quite High
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 1 99.48 Very High Very High Very High
INFLAMMATION 58 99.40 Very High Very High Very High
Myocardial Infarction 52 97.96 Very High Very High Very High
Brain Injury 6 97.16 Very High Very High Very High
Diabetes Mellitus 181 96.76 Very High Very High Very High
Shock 2 95.56 Very High Very High Very High
Hypereosinophilic Syndrome 7 94.52 High High
Injury 38 94.44 High High
Eosinophilia 12 92.44 High High
Stress 5 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a strong immune-inflammatory response [54] as seen by the upregulation of JAK2, Litaf, Stat 1, and caspase 11 among others.
Positive_regulation (upregulation) of JAK2 associated with inflammatory response
1) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 1.50 Pain Relevance 0.08
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Positive_regulation (mediator) of JAK2 associated with opioid
2) Confidence 0.46 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.76
It is unclear mechanistically how CP-690,550 might spare JAK2 in cellular assays, although one explanation for reduced cellular potency could be that a cytoplasmic activator of JAK2, such as SH2-B?
Positive_regulation (activator) of JAK2 in SH2 associated with potency
3) Confidence 0.40 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0 Pain Relevance 0.23
It has previously been demonstrated that JAK2 is important in the signal transduction cascade for several hematopoietic growth factor receptors, including granulocyte-colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF) [3,14-16].
Positive_regulation (important) of JAK2 in granulocyte
4) Confidence 0.38 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.63 Pain Relevance 0.28
Erythropoietin (EPO) administration activated the Jak2-mediated signaling and limited the infarct size in experimental rats.
Positive_regulation (activated) of Jak2
5) Confidence 0.33 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.09 Pain Relevance 0.03
These include up-regulated transcription factors (SOCS-3, JAK-2, STAT-3, CREM, IRF-1, SMN, silencer factor-B, ANIA-3, ANIA-4, and HES-1) and signal transduction pathways (cpg21, Narp, and CRBP) and down-regulated transmitter release mechanisms (CITRON, synaptojanin II, ras-related rab3, neurexin-1beta, and SNAP25A and -B), kinases (IP-3-kinase, Pak1, Ca(2+)/CaM-dependent protein kinases), and ion channels (K(+) channels TWIK, RK5, X62839, and Na(+) channel I).
Positive_regulation (up-regulated) of JAK-2
6) Confidence 0.30 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12503083 Disease Relevance 0.63 Pain Relevance 0.22
7 nAChR activation of the JAK2-PI3K cascade in PC12 cells, which ultimately contribute to ?
Positive_regulation (activation) of JAK2
7) Confidence 0.24 Published 2010 Journal The Open Medicinal Chemistry Journal Section Body Doc Link PMC3023065 Disease Relevance 0.08 Pain Relevance 0.18
This workup included negative antinuclear antibodies, negative antineutrophil cytoplasmic antibodies, negative marrow exam for malignancy, negative CHIC2 studies, negative JAK2 mutation analysis, normal serum IL-5, and negative flow cytometry for immunophenotypically abnormal T-cells associated with lymphocytic hypereosinophilic syndrome.
Positive_regulation (negative) of JAK2 in T-cells associated with malignant neoplastic disease and hypereosinophilic syndrome
8) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2830978 Disease Relevance 1.19 Pain Relevance 0.22

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