INT107454

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 2003
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 43
Total Number 43
Disease Relevance 19.63
Pain Relevance 17.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat3) nucleolus (Stat3) plasma membrane (Stat3)
nucleus (Stat3) DNA binding (Stat3) transcription factor binding (Stat3)
Anatomy Link Frequency
SNL 2
spinal cord 2
hypothalamus 2
CCI 2
endothelial cells 2
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 33 100.00 Very High Very High Very High
Spinal cord 36 99.84 Very High Very High Very High
qutenza 50 99.82 Very High Very High Very High
cytokine 116 99.72 Very High Very High Very High
Potency 70 99.72 Very High Very High Very High
Sciatic nerve 32 99.68 Very High Very High Very High
Opioid 15 99.26 Very High Very High Very High
Nerve growth factor 15 98.92 Very High Very High Very High
intrathecal 6 98.92 Very High Very High Very High
Peripheral nerve injury 14 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 415 99.84 Very High Very High Very High
Injury 44 99.72 Very High Very High Very High
Reprotox - General 1 4 99.72 Very High Very High Very High
Heart Arrhythmia 574 99.58 Very High Very High Very High
Fibrosis 16 98.68 Very High Very High Very High
Nervous System Injury 14 98.28 Very High Very High Very High
INFLAMMATION 324 98.06 Very High Very High Very High
Neuropathic Pain 28 98.00 Very High Very High Very High
Hyperalgesia 26 97.78 Very High Very High Very High
Brain Injury 8 97.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrates that a capsaicin impairment of small diameter primary sensory neurons followed by an NGF treatment evokes a characteristic pattern of ERK and STAT3 activation indicative of neuronal degeneration and regeneration.
Positive_regulation (activation) of STAT3 in primary sensory neurons associated with nerve growth factor and qutenza
1) Confidence 0.68 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0 Pain Relevance 0.87
In naive rats, intrathecal administration of a proalgesic cytokine IL-6 rapidly activated microglial JAK/STAT3 and induced downstream changes closely resembling CCI-evoked alterations.
Positive_regulation (activated) of STAT3 in CCI associated with sciatic nerve, cytokine and intrathecal
2) Confidence 0.63 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.63 Pain Relevance 1.05
Ligation of L5-L6 spinal nerves (SNL) evoked an accumulation of active, phosphorylated form of STAT3 in microglial cells of dorsal spinal cord mostly in projection areas of injured nerves.
Positive_regulation (accumulation) of STAT3 in spinal cord associated with spinal cord
3) Confidence 0.63 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.62 Pain Relevance 0.81
In the present investigation, the time courses of the induction of phospho-MAPK/ERK1/2 and of phospho-STAT3 were investigated in the dorsal root ganglia (DRG) and in the sciatic nerve of rats following a systemic capsaicin treatment without or with concomitant intraplantar NGF injections.
Positive_regulation (induction) of STAT3 in dorsal root ganglia associated with qutenza and sciatic nerve
4) Confidence 0.49 Published 2005 Journal Pharmacology Section Abstract Doc Link 16141720 Disease Relevance 0.10 Pain Relevance 0.41
In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E(2) (PGE(2)) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS.
Positive_regulation (induction) of signal transducer and activator of transcription 3 in endothelial cells associated with thermal hyperalgesia
5) Confidence 0.47 Published 2007 Journal Neuroscience Section Abstract Doc Link 17303338 Disease Relevance 1.12 Pain Relevance 0.64
In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E(2) (PGE(2)) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS.
Positive_regulation (induction) of STAT3 in endothelial cells associated with thermal hyperalgesia
6) Confidence 0.47 Published 2007 Journal Neuroscience Section Abstract Doc Link 17303338 Disease Relevance 1.12 Pain Relevance 0.64
Morphine phosphorylated STAT3, Akt, and GSK-3beta, and phosphorylation was abrogated by AG-490.
Positive_regulation (abrogated) of STAT3 associated with morphine
7) Confidence 0.45 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.70
These data suggest that OIC occurs via the JAK2 regulation of PI3K pathway-dependent STAT3, Akt, and GSK-3 beta, with GSK-3 beta contributing a central role in acute OIC.
Positive_regulation (pathway-dependent) of STAT3
8) Confidence 0.45 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.13 Pain Relevance 0.41
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Positive_regulation (mediator) of STAT3 associated with opioid
9) Confidence 0.45 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16517948 Disease Relevance 0.22 Pain Relevance 0.76
We identified downstream mechanisms through which JAK/STAT3 pathway activation leads to the spreading of neuroinflammation.
Positive_regulation (activation) of STAT3
10) Confidence 0.45 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20410127 Disease Relevance 0.55 Pain Relevance 0.98
Intrathecal injection of anti-rat IL-6 antibodies prevented the SNL-induced accumulation of phospho-STAT3 in the spinal cord.
Positive_regulation (accumulation) of STAT3 in SNL associated with spinal cord and intrathecal
11) Confidence 0.45 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.66 Pain Relevance 0.90
We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling.
Positive_regulation (activation) of STAT3 in SGC associated with eae, injury and sciatic nerve
12) Confidence 0.45 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20519054 Disease Relevance 0.68 Pain Relevance 0.65
We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling.
Positive_regulation (activation) of signal transducer and activator of transcription 3 in SGC associated with eae, injury and sciatic nerve
13) Confidence 0.45 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20519054 Disease Relevance 0.67 Pain Relevance 0.65
The cell lysates were then subject to western blotting for evidence of STAT-3 and AKT activation.


Positive_regulation (activation) of STAT-3
14) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
The central effects of HN on insulin action were associated with activation of hypothalamic STAT-3 signaling; effects that were negated by co-inhibition of hypothalamic STAT-3.
Positive_regulation (activation) of STAT-3
15) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2709436 Disease Relevance 0.90 Pain Relevance 0
Activation of STAT-3 in the hypothalamus is critical for the effects of HN on glucose metabolism
Positive_regulation (Activation) of STAT-3 in hypothalamus
16) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0 Pain Relevance 0
We also demonstrate that hypothalamic STAT-3 activation is required for the insulin-sensitizing action of HN.
Positive_regulation (activation) of STAT-3
17) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.15 Pain Relevance 0
These data show that in response to SNL injury Janus kinase/STAT3 system is activated mainly through IL-6 signaling in spinal microglia and that this transduction pathway participates in development of pain associated with nerve alteration.
Positive_regulation (activated) of STAT3 in SNL associated with pain and injury
18) Confidence 0.42 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.75 Pain Relevance 0.88
Capsaicin evoked a four- to fivefold increase in phospho-STAT3 in the sciatic nerve and a twofold increase in the DRG at 3 and 6 h after the treatment.
Positive_regulation (increase) of STAT3 in DRG associated with qutenza and sciatic nerve
19) Confidence 0.40 Published 2006 Journal Pharmacology Section Abstract Doc Link 16788306 Disease Relevance 0 Pain Relevance 1.16
SR140333 less markedly attenuated the capsaicin-induced increase in phosphorylated STAT3: whereas in the sciatic nerve the difference was significant when the data at 3 h and 6 h were combined (p < 0.05), no such treatment effect of SR140333 was observed in the DRG.
Positive_regulation (increase) of STAT3 in sciatic nerve associated with qutenza and sciatic nerve
20) Confidence 0.40 Published 2006 Journal Pharmacology Section Abstract Doc Link 16788306 Disease Relevance 0 Pain Relevance 1.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox