INT107462

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.78
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Jak2) cytosol (Jak2) signal transduction (Jak2)
histone binding (Jak2) cytoskeleton (Jak2) nucleus (Jak2)
Jak2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 90.24 High High
Potency 26 83.36 Quite High
anesthesia 2 80.92 Quite High
rheumatoid arthritis 22 74.64 Quite High
Neuropeptide 1 66.96 Quite High
Glutamate receptor 1 65.44 Quite High
Inflammation 21 54.96 Quite High
cytokine 29 47.12 Quite Low
psoriasis 3 13.36 Low Low
Arthritis 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 6 95.40 Very High Very High Very High
Injury 1 92.68 High High
Death 1 79.76 Quite High
Rheumatoid Arthritis 22 74.64 Quite High
Shock 1 70.08 Quite High
INFLAMMATION 20 54.96 Quite High
Psoriasis 3 13.36 Low Low
Arthritis 52 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Immunization 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If JAK2 sensitivity to CP-690,550 is indeed reduced in cells, our findings suggest that inhibition of the enzyme may not be required to block signaling through receptors for IL-6 and IFN-?
Localization (sensitivity) of JAK2
1) Confidence 0.60 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2928212 Disease Relevance 0.13 Pain Relevance 0.17
These include up-regulated transcription factors (SOCS-3, JAK-2, STAT-3, CREM, IRF-1, SMN, silencer factor-B, ANIA-3, ANIA-4, and HES-1) and signal transduction pathways (cpg21, Narp, and CRBP) and down-regulated transmitter release mechanisms (CITRON, synaptojanin II, ras-related rab3, neurexin-1beta, and SNAP25A and -B), kinases (IP-3-kinase, Pak1, Ca(2+)/CaM-dependent protein kinases), and ion channels (K(+) channels TWIK, RK5, X62839, and Na(+) channel I).
Localization (release) of JAK-2
2) Confidence 0.43 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12503083 Disease Relevance 0.65 Pain Relevance 0.23

General Comments

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