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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) plasma membrane (Atrn)
cytoplasm (Atrn)
Anatomy Link Frequency
melanocytes 1
nervous system 1
Atrn (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 70 99.72 Very High Very High Very High
antagonist 4 70.88 Quite High
agonist 4 68.44 Quite High
Neuropeptide 1 67.40 Quite High
Kinase C 1 23.52 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 99.08 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 94.44 High High
Freckles 51 79.00 Quite High
Skin Cancer 2 25.36 Quite Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Vibrio Infection 3 5.00 Very Low Very Low Very Low
Microphthalmia 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melanocortin receptors and ATRN are the only molecules known to bind ASIP (Abdel-Malek et al., 2001; He et al., 2003).
ATRN Binding (bind) of
1) Confidence 0.43 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.12
We suggest that the neurodegenerative phenotype reflects the ancestral function of Atrn to facilitate and/or maintain cell-cell interactions in the nervous system.
Atrn Binding (interactions) of in nervous system associated with neurodegenerative disease
2) Confidence 0.29 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503608 Disease Relevance 0.19 Pain Relevance 0.13
The protein products of three of these genes, Mc1r, Agouti, and Atrn, interact at the surface of pigment-producing cells (melanocytes) and constitute the machinery responsible for “pigment type switching,” the ability of melanocytes to switch between the production of dark brown/black (eumelanin) and light yellow/red pigment (pheomelanin).
Atrn Binding (interact) of in melanocytes associated with melanocortin 1 receptor
3) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.16 Pain Relevance 0.49

General Comments

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