INT107468

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.47
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Atrn) extracellular space (Atrn) plasma membrane (Atrn)
cytoplasm (Atrn)
Anatomy Link Frequency
pigmentation 3
melanocytes 1
Atrn (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 96.84 Very High Very High Very High
antagonist 4 93.60 High High
melanocortin 1 receptor 61 92.20 High High
Neuropeptide 2 88.48 High High
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 5 99.98 Very High Very High Very High
Body Weight 1 94.56 High High
Attention Deficit Hyperactivity Disorder 2 72.88 Quite High
Neurodegenerative Disease 2 65.76 Quite High
Microphthalmia 4 28.80 Quite Low
Sprains And Strains 10 8.16 Low Low
Vibrio Infection 6 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Skin Cancer 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Atrn(mg-3J) and dal showed additive effects on pigmentation, testicular vacuolation, and spongiform neurodegeneration, but transgenic overexpression of Attractin-like-1 (Atrnl1), which compensates for loss of ATRN, did not rescue dal mutant phenotypes.
Gene_expression (overexpression) of Attractin in pigmentation associated with targeted disruption
1) Confidence 0.76 Published 2008 Journal Genesis Section Abstract Doc Link 18821597 Disease Relevance 0.19 Pain Relevance 0.09
Recently we have used the genetics of pigmentation as an in vivo screening system to analyze other mutations in the Agouti-melanocortin pathway, leading to the identification of Attractin (Atrn), a widely expressed type I transmembrane protein that serves as an accessory receptor for Agouti protein.
Gene_expression (expressed) of Attractin in pigmentation
2) Confidence 0.70 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503608 Disease Relevance 0.14 Pain Relevance 0.17
Recently we have used the genetics of pigmentation as an in vivo screening system to analyze other mutations in the Agouti-melanocortin pathway, leading to the identification of Attractin (Atrn), a widely expressed type I transmembrane protein that serves as an accessory receptor for Agouti protein.
Gene_expression (expressed) of Atrn in pigmentation
3) Confidence 0.70 Published 2002 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 12503608 Disease Relevance 0.14 Pain Relevance 0.17
Atrn and Mgrn1-null melanocytes: partial biological responses to ASIP but not ASIP-YY
Gene_expression (melanocytes) of Atrn in melanocytes
4) Confidence 0.61 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
Mice with null mutations at the attractin (Atrn, formerly mahogany) or mahogunin (Mgrn1, formerly mahoganoid) loci produce eumelanin and no pheomelanin, even in the presence of ASIP (He et al., 2001, 2003).
Neg (no) Gene_expression (produce) of Atrn
5) Confidence 0.53 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.54

General Comments

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