INT107477

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Context Info
Confidence 0.30
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.88
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) endosome (Ntrk1) aging (Ntrk1)
plasma membrane (Ntrk1) cytoplasm (Ntrk1)
Anatomy Link Frequency
spinal 2
spinal cord 2
Ntrk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 2 99.84 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
Pain 9 99.60 Very High Very High Very High
nociceptor 6 99.60 Very High Very High Very High
central pain 2 95.36 Very High Very High Very High
Inflammation 7 82.72 Quite High
Hyperalgesia 7 81.68 Quite High
Acute pain 2 78.48 Quite High
intrathecal 3 65.52 Quite High
nMDA receptor antagonist 1 57.84 Quite High
Disease Link Frequency Relevance Heat
Pain 7 95.04 Very High Very High Very High
INFLAMMATION 4 82.72 Quite High
Hyperalgesia 8 81.68 Quite High
Sleep Disorders 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity.
Positive_regulation (enhance) of Phosphorylation (Phosphorylation) of Trk
1) Confidence 0.30 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12754057 Disease Relevance 0.54 Pain Relevance 0.51
We found that noxious chemical, mechanical, or thermal stimuli, but not innocuous stimuli, caused Trk phosphorylation in the spinal cord.
Positive_regulation (caused) of Phosphorylation (phosphorylation) of Trk in spinal cord associated with spinal cord
2) Confidence 0.08 Published 2002 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 12504600 Disease Relevance 0.17 Pain Relevance 0.42
Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of Trk in spinal associated with nociceptor and spinal dorsal horn
3) Confidence 0.06 Published 2002 Journal Mol. Cell. Neurosci. Section Title Doc Link 12504600 Disease Relevance 0.17 Pain Relevance 0.93

General Comments

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