INT107514

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.64
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Akr1b1) oxidoreductase activity (Akr1b1) nucleolus (Akr1b1)
nucleus (Akr1b1) cytoplasm (Akr1b1)
Anatomy Link Frequency
poly 1
nerve 1
corneal epithelium 1
Akr1b1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 2 99.92 Very High Very High Very High
Peripheral nervous system 1 98.48 Very High Very High Very High
Pain 11 94.20 High High
fluoxetine 4 93.76 High High
Hyperalgesia 8 92.72 High High
Inflammation 10 90.72 High High
antidepressant 4 87.60 High High
withdrawal 4 85.40 High High
Brush evoked pain 1 84.48 Quite High
diabetic neuropathy 8 83.60 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 112 98.56 Very High Very High Very High
Hyperglycemia 20 98.04 Very High Very High Very High
Congenital Anomalies 5 97.48 Very High Very High Very High
Adhesions 7 96.44 Very High Very High Very High
Neuropathic Pain 7 96.20 Very High Very High Very High
Injury 4 95.44 Very High Very High Very High
Stress 23 94.44 High High
Hyperalgesia 9 92.72 High High
Cataract 21 92.00 High High
INFLAMMATION 12 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data also support the idea of activation of aldose reductase and polyol pathway as an important mechanism of hyperglycemia-induced impairment of nerve function.
Positive_regulation (activation) of aldose reductase in nerve associated with hyperglycemia
1) Confidence 0.70 Published 2003 Journal Brain Res. Section Abstract Doc Link 12505670 Disease Relevance 0.98 Pain Relevance 0.71
Animal studies using pharmacological and genetic approaches revealed important roles of increased aldose reductase, protein kinase C, and poly(ADP-ribose) polymerase activities, advanced glycation end-products and their receptors, oxidative-nitrosative stress, growth factor imbalances, and C-peptide deficiency in both painful and insensate neuropathy.
Positive_regulation (increased) of aldose reductase in poly associated with stress, pain, kinase c and neuropathic pain
2) Confidence 0.26 Published 2009 Journal Neurotherapeutics Section Abstract Doc Link 19789069 Disease Relevance 2.48 Pain Relevance 1.48
After GR205171 treatment, protein disulphide isomerase A was reduced; dynamin 1 and aldose reductase increased.
Positive_regulation (increased) of aldose reductase
3) Confidence 0.23 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16517129 Disease Relevance 0.15 Pain Relevance 0.69
These are protein kinase C (PKC) activation, advanced glycation end-products (AGE), increased aldose reductase and hexosamine pathway fluxes.
Positive_regulation (increased) of aldose reductase associated with kinase c
4) Confidence 0.22 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2939516 Disease Relevance 1.35 Pain Relevance 0.26
Methylglyoxal also induces aldose reductase which is known to stimulate flux of glucose through the polyol pathway with further formation of methylglyoxal (Chang et al 2002).
Positive_regulation (induces) of aldose reductase
5) Confidence 0.07 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993980 Disease Relevance 0.68 Pain Relevance 0
In addition, erythrocyte aldose reductase increase has been reported in patients with type 2 diabetes, leading to high accumulation of sorbitol, which can damage the corneal epithelium (133).
Positive_regulation (increase) of aldose reductase in corneal epithelium associated with diabetes mellitus
6) Confidence 0.02 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518369 Disease Relevance 1.87 Pain Relevance 0.07

General Comments

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