INT107522

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2010
Negated 0
Speculated 7
Reported most in Abstract
Documents 9
Total Number 16
Disease Relevance 6.42
Pain Relevance 11.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
neurons 2
CeA 2
plasma 1
spinal cord 1
striatum 1
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 64 100.00 Very High Very High Very High
Glutamate 34 100.00 Very High Very High Very High
Glutamate receptor 19 100.00 Very High Very High Very High
Neuropathic pain 4 100.00 Very High Very High Very High
Analgesic 4 99.98 Very High Very High Very High
nociceptor 6 99.96 Very High Very High Very High
Spinal cord 12 99.84 Very High Very High Very High
Pain 96 99.80 Very High Very High Very High
IPN 3 99.80 Very High Very High Very High
amygdala 91 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 100.00 Very High Very High Very High
Inflammatory Pain 3 99.80 Very High Very High Very High
Pain 84 99.40 Very High Very High Very High
Arthritis 68 99.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

7 99.20 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

5 97.04 Very High Very High Very High
Depression 3 97.04 Very High Very High Very High
INFLAMMATION 9 96.80 Very High Very High Very High
Anxiety Disorder 7 96.40 Very High Very High Very High
Sprains And Strains 3 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we address the roles of mGluR1 and mGluR5 subtypes in the CeA in the modulation of supraspinally organized behavioral responses in a model of arthritic pain.
Regulation (roles) of mGluR5 in CeA associated with pain, amygdala and arthritis
1) Confidence 0.44 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 0.95 Pain Relevance 1.03
These findings suggest differential roles of mGluR1 and mGluR5 in the CeA in pain-related vocalizations.
Regulation (roles) of mGluR5 in CeA associated with pain and amygdala
2) Confidence 0.44 Published 2005 Journal Pain Section Abstract Doc Link 15621382 Disease Relevance 0.81 Pain Relevance 1.05
Since the metabotropic glutamate (mGlu) 5 receptor has been shown to affect glutamate release and modulate NMDA receptor function, we examined the effects of two selective mGlu5 receptor antagonists, 2-methyl-6-(phenyl-ethynyl)-pyridine (MPEP) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP), on morphine withdrawal.
Spec (examined) Regulation (effects) of mGlu5 associated with glutamate, antagonist, nmda receptor, withdrawal and morphine
3) Confidence 0.43 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15695156 Disease Relevance 0.19 Pain Relevance 1.02
In this study we examined the effects of the glutamate metabotropic subtype 5 (mGlu5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) on Fos expression in the spinal cord in a model of visceral pain in the rat.
Spec (examined) Regulation (effects) of mGlu5 in spinal cord associated with visceral pain, glutamate, antagonist and spinal cord
4) Confidence 0.41 Published 2003 Journal Brain Res. Section Abstract Doc Link 12505681 Disease Relevance 0 Pain Relevance 0.46
We evaluated effects of mGluR5 antagonists on the colorectal distension (CRD)-evoked visceromotor (VMR) and cardiovascular responses in conscious rats, and on mechanosensory responses of mouse colorectal afferents in vitro.
Regulation (effects) of mGluR5 associated with antagonist
5) Confidence 0.40 Published 2008 Journal Pain Section Abstract Doc Link 17937975 Disease Relevance 0.19 Pain Relevance 0.53
This study investigated the role of one subtype of Group I receptors, mGluR5, in the regulation of PPE mRNA expression in the rat dorsal striatum using quantitative in situ hybridization.
Spec (investigated) Regulation (role) of mGluR5 in striatum
6) Confidence 0.36 Published 2003 Journal Synapse Section Abstract Doc Link 12539198 Disease Relevance 0 Pain Relevance 0.20
Like the mGluR1 antagonist, a selective mGluR5 antagonist (MTEP, 1 ?
Regulation (Like) of mGluR5 associated with antagonist
7) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC3016348 Disease Relevance 0.55 Pain Relevance 0.56
In the present study, we examined the effect of the selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MTEP) on operant ethanol self-administration by two strains of rats, the Fawn-Hooded (FH) rat and the inbred alcohol-preferring (iP) rat.
Spec (examined) Regulation (effect) of mGlu5 receptor associated with antagonist, sprains and strains and alcohol
8) Confidence 0.30 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16014750 Disease Relevance 0.66 Pain Relevance 0.43
The present study aimed at determining whether persistent inflammatory pain produces alterations in intracellular and plasma membrane-associated mGluR1alpha and mGluR5 in spinal cord dorsal horn.
Spec (whether) Regulation (alterations) of mGluR5 in plasma associated with ipn, dorsal horn and spinal cord
9) Confidence 0.27 Published 2007 Journal J. Comp. Neurol. Section Abstract Doc Link 17912745 Disease Relevance 0.45 Pain Relevance 0.74
A selective mGluR1 antagonist reduced transmission in CeA neurons from arthritic animals but not in control neurons, and increased levels of mGluR1 and mGluR5 protein were measured in the CeA of arthritic rats compared with controls.
Regulation (measured) of mGluR5 protein in neurons associated with antagonist, amygdala and arthritis
10) Confidence 0.26 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.83 Pain Relevance 1.13
These results suggest that NSIA depends on glutamate, released from the central terminals of the primary afferent nociceptors, acting primarily on NMDA and mGluR5 receptors.
Regulation (acting) of mGluR5 in nociceptors associated with antinociception, glutamate and nociceptor
11) Confidence 0.26 Published 2003 Journal Pain Section Abstract Doc Link 14581125 Disease Relevance 0 Pain Relevance 1.36
Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.
Regulation (immunoreactivities) of mGluR5 in neurons associated with glutamate
12) Confidence 0.26 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.84
OBJECTIVE: To investigate the expression changes of metabotropic glutamate receptor 5 (mGluR5) in neuropathic pain.
Spec (investigate) Regulation (changes) of mGluR5 associated with glutamate receptor and neuropathic pain
13) Confidence 0.26 Published 2007 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Abstract Doc Link 17380680 Disease Relevance 0.17 Pain Relevance 0.26
The data presented here suggest that this component of the dependence may be preferentially sensitive to mGluR5 receptor blockade.
Spec (may) Regulation (sensitive) of mGluR5 receptor associated with addiction
14) Confidence 0.19 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2885299 Disease Relevance 0.29 Pain Relevance 0.41
Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.
Regulation (effects) of mGlu5 associated with antagonist and analgesic
15) Confidence 0.16 Published 2006 Journal Neuropharmacology Section Title Doc Link 16793067 Disease Relevance 0.58 Pain Relevance 1.43
Nonetheless, the data presented here suggest a novel role for Siah1a and CaM in regulating the function of group I mGluRs.
Regulation (regulating) of mGluRs
16) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

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