INT107524

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 7.93
Pain Relevance 11.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
brain 2
amygdala 2
sciatic nerve 1
neurons 1
Lever 1
Faah (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 255 100.00 Very High Very High Very High
Cannabinoid receptor 50 99.90 Very High Very High Very High
Analgesic 94 99.76 Very High Very High Very High
Central nervous system 19 99.68 Very High Very High Very High
Cannabinoid 119 99.48 Very High Very High Very High
Spinal cord 83 99.40 Very High Very High Very High
depression 82 98.96 Very High Very High Very High
Sciatic nerve 10 98.72 Very High Very High Very High
Paracetamol 276 98.38 Very High Very High Very High
Antinociceptive 112 97.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 32 99.88 Very High Very High Very High
Ileus 12 99.34 Very High Very High Very High
Sepsis 30 99.06 Very High Very High Very High
Depression 82 98.96 Very High Very High Very High
Nervous System Injury 37 98.40 Very High Very High Very High
Hyperalgesia 34 97.12 Very High Very High Very High
Pressure And Volume Under Development 3 96.44 Very High Very High Very High
Pain 114 94.32 High High
INFLAMMATION 71 93.80 High High
Demyelinating Disease 9 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in FAAH expression was completely reversed by cannabidiol but not affected by AM251.
Gene_expression (expression) of FAAH
1) Confidence 0.78 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.72 Pain Relevance 0.29
Sepsis was associated with a selective upregulation of intestinal CB(1) receptors without affecting CB(2) receptor expression and with increased FAAH expression.
Gene_expression (expression) of FAAH associated with sepsis
2) Confidence 0.78 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 0.73 Pain Relevance 0.29
Because of the therapeutic potential of cannabidiol in several pathologies, we investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine.
Gene_expression (expression) of FAAH in intestine associated with ileus, cannabinoid receptor and sepsis
3) Confidence 0.78 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18373655 Disease Relevance 1.05 Pain Relevance 0.29
These changes were not due to differences in the expression of the degradation enzymes, fatty acid amide hydrolase and monoacylglycerol lipase, or of biosynthetic enzymes, diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine phospholipase-D at this time (60 days).
Gene_expression (expression) of fatty acid amide hydrolase
4) Confidence 0.69 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18657182 Disease Relevance 0.61 Pain Relevance 0.84
FAAH has been shown to be (among others) strongly expressed in the basolateral complex of the amygdala (BLA; composed of the LA, BL and the basomedial nucleus), but is nearly absent in the central complex of the amygdala of rats [60].
Gene_expression (expressed) of FAAH in amygdala associated with amygdala
5) Confidence 0.59 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.05 Pain Relevance 0.66
Collectively, these studies promote FAAH as a central component of FAA signaling pathways, especially those mediated by the endocannabinoid anandamide, and suggest that this enzyme may represent an attractive pharmaceutical target for the treatment of pain and related neurophysiological disorders.
Gene_expression (promote) of FAAH associated with pain and endocannabinoid
6) Confidence 0.56 Published 2002 Journal Chem. Phys. Lipids Section Abstract Doc Link 12505696 Disease Relevance 0.16 Pain Relevance 0.33
Second, we found that inhibition of the anandamide-hydrolysing enzyme, fatty acid amide hydrolase (FAAH), which is also expressed by a major sub-population of TRPV1-expressing primary sensory neurons results in TRPV1 activity (Lever et al., 2009).
Gene_expression (expressed) of FAAH in Lever
7) Confidence 0.56 Published 2009 Journal Neuroscience Section Body Doc Link PMC2724038 Disease Relevance 0.31 Pain Relevance 0.24
Transgenic mice expressing FAAH exclusively on neurons continued to display the antiedematous, but not the antihyperalgesic, phenotype.
Gene_expression (expressing) of FAAH in neurons associated with targeted disruption and antihyperalgesic
8) Confidence 0.52 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20375198 Disease Relevance 0.84 Pain Relevance 1.04
In a microarray screen of gene regulation in the DRGs and spinal cord, we found a long lasting upregulation of FAAH expression in the DRGs in three models of sciatic nerve injury (Fig. 3 a) associated with a drop of endocannabinoids.
Gene_expression (on) of FAAH in sciatic nerve associated with endocannabinoid, nervous system injury, sciatic nerve and spinal cord
9) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 0.39 Pain Relevance 1.03
Hydrolysing enzymes include fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and N-acylethanolamine-hydrolysing acid amidase (NAAA).
Gene_expression (include) of FAAH
10) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.48 Pain Relevance 0.76
Hydrolysing enzymes include fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and N-acylethanolamine-hydrolysing acid amidase (NAAA).
Gene_expression (include) of fatty acid amide hydrolase
11) Confidence 0.48 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.48 Pain Relevance 0.76
In conclusion, we provide evidence that TRPV1 in brain mediates the antinociceptive effect of acetaminophen and propose a strategy for developing TRPV1 active oral analgesics based on the coexpression of TRPV1 and FAAH in the central nervous system.


Gene_expression (coexpression) of FAAH in central nervous system associated with paracetamol, analgesic, central nervous system and antinociceptive
12) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941447 Disease Relevance 0.26 Pain Relevance 0.83
FAAH has been shown to be (among others) strongly expressed in the basolateral complex of the amygdala (BLA; composed of the LA, BL and the basomedial nucleus), but is nearly absent in the central complex of the amygdala of rats [60].
Neg (absent) Gene_expression (absent) of FAAH in amygdala associated with amygdala
13) Confidence 0.46 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.05 Pain Relevance 0.78
Role of PPARs in mediating analgesic effects of FAAH inhibition
Neg (inhibition) Gene_expression (inhibition) of FAAH associated with analgesic
14) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.39 Pain Relevance 0.98
Besides the brain, the spinal cord and dorsal root ganglia also express FAAH [12], [37], [38].
Gene_expression (express) of FAAH in brain associated with spinal cord
15) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941447 Disease Relevance 0.22 Pain Relevance 1.12
In contrast, blockade of the Fatty Acid Amide Hydrolase, the enzyme that breaks anandamide down, with the specific inhibitor URB597 (2 ┬ÁM) had no effect (Fig 6D).
Gene_expression (blockade) of Fatty Acid Amide Hydrolase
16) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.77 Pain Relevance 0.42
In contrast, blocking anandamide degradation (using the FAAH inhibitor URB597) had no effect.
Gene_expression (using) of FAAH
17) Confidence 0.40 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.26 Pain Relevance 0.16
This study shows that TRPV1 in brain is involved in the antinociceptive action of acetaminophen and provides a strategy for developing central nervous system active oral analgesics based on the coexpression of FAAH and TRPV1 in the brain.



Gene_expression (coexpression) of FAAH in brain associated with paracetamol, analgesic, central nervous system and antinociceptive
18) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941447 Disease Relevance 0.13 Pain Relevance 1.10

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