INT107525

Context Info Confidence 0.60 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 1.54 Pain Relevance 2.78

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah) cytoplasm (Faah)

Anatomy Link Frequency skin 1 Faah (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 92 98.86 Antinociceptive 41 98.38 Endocannabinoid 53 97.48 Multiple sclerosis 1 95.80 analgesia 2 94.28 Pain 17 91.52 Cannabinoid 17 90.24 Brush evoked pain 1 85.56 Inflammation 10 81.68 Opioid 1 76.12

Disease Link Frequency Relevance Heat Bone Cancer 2 98.08 Disease 3 97.20 Demyelinating Disease 1 95.80 Nervous System Injury 34 91.76 Pain 17 91.52 Neuropathic Pain 33 85.56 INFLAMMATION 10 81.68 Cancer Pain 1 70.16 Injury 11 64.96 Nociception 22 64.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, a similar decrease of anandamide as a result of increased FAAH activity was recently found in the paw skin in bone cancer bearing mice [12].

Positive_regulation (increased) of FAAH in skin associated with bone cancer

1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.30 Pain Relevance 0.94

Collectively, these studies promote FAAH as a central component of FAA signaling pathways, especially those mediated by the endocannabinoid anandamide, and suggest that this enzyme may represent an attractive pharmaceutical target for the treatment of pain and related neurophysiological disorders.

Positive_regulation (promote) of FAAH associated with pain and endocannabinoid

2) Confidence 0.39 Published 2002 Journal Chem. Phys. Lipids Section Abstract Doc Link 12505696 Disease Relevance 0.16 Pain Relevance 0.33

These results indicate that the blockade of anandamide uptake observed with LY2183240 may be due primarily to the inactivation of FAAH, providing further evidence that this enzyme serves as a metabolic driving force that promotes the diffusion of anandamide into cells.

Positive_regulation (inactivation) of FAAH

3) Confidence 0.34 Published 2006 Journal J. Am. Chem. Soc. Section Abstract Doc Link 16866524 Disease Relevance 0 Pain Relevance 0.28

LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile.

Positive_regulation (inactivates) of FAAH

4) Confidence 0.30 Published 2006 Journal J. Am. Chem. Soc. Section Abstract Doc Link 16866524 Disease Relevance 0 Pain Relevance 0.32

Although the mechanisms behind these effects remain to be determined, our study clearly shows that the antinociceptive effect of acetaminophen at an oral dose of 200 mg/kg is independent of COX, but dependent on both FAAH and TRPV1.

Positive_regulation (dependent) of FAAH associated with paracetamol and antinociceptive

5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941447 Disease Relevance 0.08 Pain Relevance 0.91

General Comments

This test has worked.