INT107525

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.54
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Faah) Golgi apparatus (Faah) endoplasmic reticulum (Faah)
cytoplasm (Faah)
Anatomy Link Frequency
skin 1
Faah (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 92 98.86 Very High Very High Very High
Antinociceptive 41 98.38 Very High Very High Very High
Endocannabinoid 53 97.48 Very High Very High Very High
Multiple sclerosis 1 95.80 Very High Very High Very High
analgesia 2 94.28 High High
Pain 17 91.52 High High
Cannabinoid 17 90.24 High High
Brush evoked pain 1 85.56 High High
Inflammation 10 81.68 Quite High
Opioid 1 76.12 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 2 98.08 Very High Very High Very High
Disease 3 97.20 Very High Very High Very High
Demyelinating Disease 1 95.80 Very High Very High Very High
Nervous System Injury 34 91.76 High High
Pain 17 91.52 High High
Neuropathic Pain 33 85.56 High High
INFLAMMATION 10 81.68 Quite High
Cancer Pain 1 70.16 Quite High
Injury 11 64.96 Quite High
Nociception 22 64.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, a similar decrease of anandamide as a result of increased FAAH activity was recently found in the paw skin in bone cancer bearing mice [12].
Positive_regulation (increased) of FAAH in skin associated with bone cancer
1) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2869361 Disease Relevance 1.30 Pain Relevance 0.94
Collectively, these studies promote FAAH as a central component of FAA signaling pathways, especially those mediated by the endocannabinoid anandamide, and suggest that this enzyme may represent an attractive pharmaceutical target for the treatment of pain and related neurophysiological disorders.
Positive_regulation (promote) of FAAH associated with pain and endocannabinoid
2) Confidence 0.39 Published 2002 Journal Chem. Phys. Lipids Section Abstract Doc Link 12505696 Disease Relevance 0.16 Pain Relevance 0.33
These results indicate that the blockade of anandamide uptake observed with LY2183240 may be due primarily to the inactivation of FAAH, providing further evidence that this enzyme serves as a metabolic driving force that promotes the diffusion of anandamide into cells.
Positive_regulation (inactivation) of FAAH
3) Confidence 0.34 Published 2006 Journal J. Am. Chem. Soc. Section Abstract Doc Link 16866524 Disease Relevance 0 Pain Relevance 0.28
LY2183240 inactivates FAAH by carbamylation of the enzyme's serine nucleophile.
Positive_regulation (inactivates) of FAAH
4) Confidence 0.30 Published 2006 Journal J. Am. Chem. Soc. Section Abstract Doc Link 16866524 Disease Relevance 0 Pain Relevance 0.32
Although the mechanisms behind these effects remain to be determined, our study clearly shows that the antinociceptive effect of acetaminophen at an oral dose of 200 mg/kg is independent of COX, but dependent on both FAAH and TRPV1.


Positive_regulation (dependent) of FAAH associated with paracetamol and antinociceptive
5) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941447 Disease Relevance 0.08 Pain Relevance 0.91

General Comments

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