INT10754

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 23
Disease Relevance 21.81
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocyte 4
somatic cells 2
THP-1 2
PC-3 2
PCa (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 164 100.00 Very High Very High Very High
Chronic pancreatitis 61 100.00 Very High Very High Very High
Nav1.7 26 100.00 Very High Very High Very High
Patient controlled alalgesia 4 100.00 Very High Very High Very High
Ultiva 3 100.00 Very High Very High Very High
tetrodotoxin 46 95.76 Very High Very High Very High
Nerve growth factor 12 91.04 High High
Angina 8 89.44 High High
Opioid 1 89.00 High High
Inflammatory response 3 87.68 High High
Disease Link Frequency Relevance Heat
Prostate Cancer 680 100.00 Very High Very High Very High
Cancer 541 100.00 Very High Very High Very High
Reprotox - General 1 165 100.00 Very High Very High Very High
Pancreatic Cancer 137 100.00 Very High Very High Very High
Pancreatitis 69 100.00 Very High Very High Very High
Apoptosis 25 99.76 Very High Very High Very High
Benign Prostatic Hypertrophy 25 99.60 Very High Very High Very High
Aggression 6 98.52 Very High Very High Very High
Disease 98 98.08 Very High Very High Very High
Metastasis 145 96.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: LPS induced a significant expression of PCA at 6, 12, and 24 h, with a significantly increased production of 6-keto-PGF1 alpha, whereas the increased PGE2 production was much less pronounced.
Positive_regulation (induced) of Gene_expression (expression) of PCA
1) Confidence 0.41 Published 1995 Journal Scand. J. Gastroenterol. Section Body Doc Link 7701246 Disease Relevance 0 Pain Relevance 0
Treatment with LPS (1 to 10 g/ml) produced maximal stimulation of PCA production with a peak at 8 hr with PCA levels 20- to 30+-fold higher than controls.
Positive_regulation (stimulation) of Gene_expression (production) of PCA
2) Confidence 0.39 Published 1986 Journal J. Surg. Res. Section Abstract Doc Link 3081762 Disease Relevance 0.42 Pain Relevance 0.23
The aims of this preliminary prospective observational study were to investigate the maternal side-effects and early neonatal effects, and to assess the placental transfer of remifentanil PCA during labour.
Positive_regulation (transfer) of Gene_expression (transfer) of PCA associated with patient controlled alalgesia and ultiva
3) Confidence 0.39 Published 2005 Journal Br J Anaesth Section Abstract Doc Link 16113038 Disease Relevance 0 Pain Relevance 0.71
Assessed individually, three studies showed similar levels of BMD between PCa patients and healthy controls [21,24,37], one showed higher levels for the PCa group [12] and one showed lower levels [18].
Positive_regulation (levels) of Gene_expression (group) of PCa associated with prostate cancer
4) Confidence 0.36 Published 2010 Journal BMC Urol Section Body Doc Link PMC2882358 Disease Relevance 1.40 Pain Relevance 0
Interestingly, comparing several clinicopathological factors to CCL20 mRNA and protein expression levels we found a significant correlation with advanced T-category pointing to a role for CCL20 and CCR6 in progression of PCA.
Positive_regulation (pointing) of Gene_expression (progression) of PCA associated with pancreatic cancer
5) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.33 Pain Relevance 0.18
It has been demonstrated by others that stimulation of CCR6 bearing PCA cells with CCL20 led to increased proliferation, migration and invasion [14-16].
Positive_regulation (stimulation) of Gene_expression (bearing) of PCA associated with pancreatic cancer
6) Confidence 0.21 Published 2010 Journal J Transl Med Section Body Doc Link PMC2877001 Disease Relevance 1.44 Pain Relevance 0.15
This Pca patient population had a 2.69 times higher mean CD24 expression for Pca than for BPH.
Positive_regulation (mean) of Gene_expression (expression) of Pca associated with benign prostatic hypertrophy and prostate cancer
7) Confidence 0.16 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 1.05 Pain Relevance 0
We first evaluated arginases expression from PCa cell lines and clinical samples.
Positive_regulation (evaluated) of Gene_expression (expression) of PCa associated with reprotox - general 1
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 1.00 Pain Relevance 0
VAV3 expression decreased gradually during PCa progression, with the lowest levels observed in metastatic prostate tumors (P-value ?
Positive_regulation (during) of Gene_expression (progression) of PCa associated with prostate cancer
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.42 Pain Relevance 0
In this context, Heiser et al. vaccinated PSA RNA-transfected DCs to 13 metastatic PCa patients [77].
Positive_regulation (transfected) of Gene_expression (transfected) of PCa associated with prostate cancer
10) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.77 Pain Relevance 0.06
Survivin, an inhibitor of apoptosis, is highly overexpressed in many human tumors including PCa, and its expression correlates with aggressiveness and poor prognosis of tumor disease [54, 55].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PCa associated with cancer, aggression, prostate cancer, disease and apoptosis
11) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.82 Pain Relevance 0
Potential target structures, which are overexpressed in tumors of different origin including PCa comprise the human telomerase reverse transcriptase (hTERT), which is the catalytic subunit of telomerase, and survivin. hTERT is undetectable in most nontransformed somatic cells but is expressed in more than 85% of human tumors including PCa [52].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PCa in somatic cells associated with cancer and prostate cancer
12) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.16 Pain Relevance 0
Trp-p8 is mainly detected in the prostate and shows an overexpression in PCa of early stages and low grades [34, 51].
Positive_regulation (overexpression) of Gene_expression (overexpression) of PCa associated with prostate cancer
13) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 1.09 Pain Relevance 0
Mu et al. conducted a clinical study enrolling 20 HRPC patients, which was based on the administration of monocyte-derived DCs transfected with RNA from allogeneic PCa cell lines [79].
Positive_regulation (transfected) of Gene_expression (transfected) of PCa in monocyte associated with prostate cancer
14) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.60 Pain Relevance 0
Six patients displayed clinical stabilization of their previously progressing PCa as determined by PSA level monitoring, computerized tomography, and bone scans.
Positive_regulation (stabilization) of Gene_expression (progressing) of PCa associated with prostate cancer
15) Confidence 0.07 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2975068 Disease Relevance 0.70 Pain Relevance 0
Multiple studies have also demonstrated changes in expression of ECM molecules in advanced PCa tumor samples, such as increased expression of BSP and Cadherin 11 [36,37], or decreased coll VII expression [38].
Positive_regulation (advanced) of Gene_expression (expression) of PCa associated with cancer and prostate cancer
16) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.99 Pain Relevance 0
Multiple studies have also demonstrated changes in expression of ECM molecules in advanced PCa tumor samples, such as increased expression of BSP and Cadherin 11 [36,37], or decreased coll VII expression [38].
Positive_regulation (increased) of Gene_expression (expression) of PCa associated with cancer and prostate cancer
17) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.98 Pain Relevance 0
For example, when prostate cells are transformed with the neu oncogene, collagen IV is overexpressed in PCa cell lines PC-3 and NbE1.4 [30,31]; while laminin alone is up-regulated in NbE1.4 [31] and the calcium-independent intercellular cell adhesion molecule-7 (ICAM-1) is down-regulated in PC-3 cells [30].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of PCa in PC-3 associated with prostate cancer and adhesions
18) Confidence 0.05 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC320496 Disease Relevance 0.98 Pain Relevance 0
In reconstitution and cross-mixing experiments, only lymphocytes from patients with active unstable angina induced the expression of PCA by monocytes from both control and patient groups.
Positive_regulation (induced) of Gene_expression (expression) of PCA in monocytes
19) Confidence 0.05 Published 1992 Journal Circulation Section Body Doc Link 1516190 Disease Relevance 0 Pain Relevance 0
However, the mechanism(s) responsible for the functional VGSC expression in metastatic PCa is not known.
Positive_regulation (functional) of Gene_expression (expression) of PCa associated with sodium channel and reprotox - general 1
20) Confidence 0.05 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2211503 Disease Relevance 0.87 Pain Relevance 0.77

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