INT107554

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2002
Negated 3
Speculated 1
Reported most in Abstract
Documents 1
Total Number 9
Disease Relevance 0
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Marcks) cytoplasm (Marcks)
Anatomy Link Frequency
LGN 6
neurons 3
Marcks (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 27 99.56 Very High Very High Very High
gABA 18 99.14 Very High Very High Very High
tetrodotoxin 9 94.84 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double-label ISH revealed that MARCKS mRNA was coexpressed with mRNA of GAP-43, another PKC substrate, in neurons of both the LGN and area 17.
Transcription (coexpressed) of MARCKS in LGN associated with kinase c
1) Confidence 0.59 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.29
We performed a nonradioactive in situ hybridization histochemistry (ISH) study of the lateral geniculate nucleus (LGN) and the primary visual area (area 17) of the macaque monkey to investigate mRNA expression of the myristoylated alanine-rich C-kinase substrate (MARCKS), a major protein kinase C (PKC) substrate.
Spec (investigate) Transcription (expression) of MARCKS in lateral geniculate nucleus associated with kinase c
2) Confidence 0.57 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.13
GABA-immunoreactive neurons in layers II-VI of area 17 did not contain MARCKS mRNA.
Neg (not) Transcription (contain) of MARCKS in neurons associated with gaba
3) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.28
GABA-immunoreactive neurons in the LGN did not contain MARCKS mRNA, indicating that MARCKS mRNA is not expressed in inhibitory interneurons.
Neg (not) Transcription (contain) of MARCKS in LGN associated with gaba
4) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.26
GABA-immunoreactive neurons in the LGN did not contain MARCKS mRNA, indicating that MARCKS mRNA is not expressed in inhibitory interneurons.
Neg (not) Transcription (expressed) of MARCKS in LGN associated with gaba
5) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.27
Expression of MARCKS mRNA in lateral geniculate nucleus and visual cortex of normal and monocularly deprived macaque monkeys.
Transcription (Expression) of MARCKS in lateral geniculate nucleus
6) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Title Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.15
Double labeling using ISH and immunofluorescence revealed that MARCKS mRNA was coexpressed with the alpha-subunit of type II calcium/calmodulin-dependent protein kinase, indicating that MARCKS mRNA is also expressed in koniocellular neurons in the LGN.
Transcription (expressed) of MARCKS in neurons
7) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.20
Double labeling using ISH and immunofluorescence revealed that MARCKS mRNA was coexpressed with the alpha-subunit of type II calcium/calmodulin-dependent protein kinase, indicating that MARCKS mRNA is also expressed in koniocellular neurons in the LGN.
Transcription (coexpressed) of MARCKS in neurons
8) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.19
To determine whether the expression of MARCKS mRNA is regulated by retinal activity, we performed ISH in the LGN and area 17 of monkeys deprived of monocular visual input by tetrodotoxin.
Transcription (expression) of MARCKS in LGN associated with tetrodotoxin
9) Confidence 0.44 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.29

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