INT107555

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 1.22
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Marcks) cytoplasm (Marcks)
Anatomy Link Frequency
LGN 4
neurons 3
T cells 1
Marcks (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 252 99.80 Very High Very High Very High
narcan 2 99.72 Very High Very High Very High
gABA 12 98.40 Very High Very High Very High
tramadol 9 95.60 Very High Very High Very High
tetrodotoxin 48 94.84 High High
butorphanol 7 94.80 High High
agonist 63 90.76 High High
opioid receptor 1 78.88 Quite High
Opioid 1 75.00 Quite High
anesthesia 4 67.88 Quite High
Disease Link Frequency Relevance Heat
Injury 94 98.84 Very High Very High Very High
Apoptosis 61 84.72 Quite High
Sepsis 49 77.88 Quite High
Death 34 67.12 Quite High
Nash(non-alcoholic Steatohepatitis) 36 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Alagille Syndrome 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone reversed the reductions in MACs.
Gene_expression (reductions) of MACs associated with narcan
1) Confidence 0.58 Published 2008 Journal J. Am. Vet. Med. Assoc. Section Abstract Doc Link 18598152 Disease Relevance 0 Pain Relevance 1.48
Expression of MARCKS mRNA in lateral geniculate nucleus and visual cortex of normal and monocularly deprived macaque monkeys.
Gene_expression (Expression) of MARCKS in lateral geniculate nucleus
2) Confidence 0.55 Published 2002 Journal Vis. Neurosci. Section Title Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.15
Double labeling using ISH and immunofluorescence revealed that MARCKS mRNA was coexpressed with the alpha-subunit of type II calcium/calmodulin-dependent protein kinase, indicating that MARCKS mRNA is also expressed in koniocellular neurons in the LGN.
Gene_expression (expressed) of MARCKS in neurons
3) Confidence 0.55 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.20
To determine whether the expression of MARCKS mRNA is regulated by retinal activity, we performed ISH in the LGN and area 17 of monkeys deprived of monocular visual input by tetrodotoxin.
Gene_expression (expression) of MARCKS in LGN associated with tetrodotoxin
4) Confidence 0.55 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.29
Double labeling using ISH and immunofluorescence revealed that MARCKS mRNA was coexpressed with the alpha-subunit of type II calcium/calmodulin-dependent protein kinase, indicating that MARCKS mRNA is also expressed in koniocellular neurons in the LGN.
Gene_expression (coexpressed) of MARCKS in neurons
5) Confidence 0.55 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.19
GABA-immunoreactive neurons in the LGN did not contain MARCKS mRNA, indicating that MARCKS mRNA is not expressed in inhibitory interneurons.
Neg (not) Gene_expression (expressed) of MARCKS in LGN associated with gaba
6) Confidence 0.55 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.27
We performed a nonradioactive in situ hybridization histochemistry (ISH) study of the lateral geniculate nucleus (LGN) and the primary visual area (area 17) of the macaque monkey to investigate mRNA expression of the myristoylated alanine-rich C-kinase substrate (MARCKS), a major protein kinase C (PKC) substrate.
Spec (investigate) Gene_expression (expression) of MARCKS in lateral geniculate nucleus associated with kinase c
7) Confidence 0.49 Published 2002 Journal Vis. Neurosci. Section Abstract Doc Link 12507329 Disease Relevance 0 Pain Relevance 0.13
To assess whether synaptic activity is able to promote PKC activation we first transfected neurons with an eGFP-MARCKS construct.
Gene_expression (transfected) of eGFP-MARCKS in neurons associated with kinase c
8) Confidence 0.31 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.31
mol/L) for 30 s (S1) and then washed to allow recovery of MARCKS to baseline levels.
Gene_expression (recovery) of MARCKS
9) Confidence 0.31 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.24
In situ assessment of PKC activity using eGFP-MARCKS
Gene_expression (using) of eGFP-MARCKS associated with kinase c
10) Confidence 0.27 Published 2007 Journal Journal of Neurochemistry Section Body Doc Link PMC2658029 Disease Relevance 0 Pain Relevance 0.31
CD4+ T cells were obtained by MACS microbead method from sham, TI, CLP and TI+CLP rats and cultured with Con-A (48h), ?
Gene_expression (obtained) of MACS in T cells associated with injury
11) Confidence 0.21 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1989035 Disease Relevance 1.22 Pain Relevance 0

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