INT107577

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 12.35
Pain Relevance 24.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
ACC 6
neurons 1
lamina 1
amygdala 1
dorsal horn 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 773 100.00 Very High Very High Very High
antagonist 252 100.00 Very High Very High Very High
Pain 126 100.00 Very High Very High Very High
Inflammation 102 100.00 Very High Very High Very High
Glutamate receptor 27 100.00 Very High Very High Very High
Anterior cingulate cortex 365 99.98 Very High Very High Very High
agonist 33 99.96 Very High Very High Very High
Morphine 514 99.88 Very High Very High Very High
Opioid 64 99.64 Very High Very High Very High
Analgesic 186 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 190 99.84 Very High Very High Very High
Anxiety Disorder 137 99.64 Very High Very High Very High
Injury 92 99.64 Very High Very High Very High
INFLAMMATION 93 99.24 Very High Very High Very High
Urological Neuroanatomy 156 99.16 Very High Very High Very High
Hyperalgesia 46 99.00 Very High Very High Very High
Inflammatory Pain 39 98.56 Very High Very High Very High
Pain 287 98.16 Very High Very High Very High
Apoptosis 8 97.36 Very High Very High Very High
Neuropathic Pain 53 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of NR2B receptors in the ACC selectively reduced behavioral sensitization related to inflammation.
Negative_regulation (Inhibition) of NR2B in ACC associated with inflammation and anterior cingulate cortex
1) Confidence 0.59 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16319310 Disease Relevance 0.60 Pain Relevance 0.63
Our findings provide strong evidence that analgesic effects of Gentiopicroside involve down-regulation of NR2B receptors in the ACC to persistent inflammatory pain.
Negative_regulation (down-regulation) of NR2B in ACC associated with ipn, analgesic and anterior cingulate cortex
2) Confidence 0.57 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18410946 Disease Relevance 0.62 Pain Relevance 1.31
Down-regulation of NR2B receptors partially contributes to analgesic effects of Gentiopicroside in persistent inflammatory pain.
Negative_regulation (Down-regulation) of NR2B associated with inflammation, ipn and analgesic
3) Confidence 0.57 Published 2008 Journal Neuropharmacology Section Title Doc Link 18410946 Disease Relevance 0.54 Pain Relevance 1.64
Considering the NMDA receptor mediated currents are largely carried out by NR2A-containing NMDA receptors, one expects that inhibition of NR2B receptor alone may not be sufficient to produce complete blockade of synaptic potentiation.
Negative_regulation (inhibition) of NR2B associated with nmda receptor
4) Confidence 0.53 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 0.76
There are at least three possible physiological significances for the reduction in NMDA receptor NR2B functions [37].
Spec (possible) Negative_regulation (reduction) of NR2B associated with nmda receptor
5) Confidence 0.53 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.74 Pain Relevance 0.64
Moreover, inhibition of the NMDA receptor subunit NR2A or NR2B induced a differential short-term versus delayed increase in the apoptosis rate, respectively.
Negative_regulation (inhibition) of NR2B associated with nmda receptor and apoptosis
6) Confidence 0.51 Published 2008 Journal Cereb. Cortex Section Abstract Doc Link 17965127 Disease Relevance 0.51 Pain Relevance 0.39
NR2B inhibition affects opioid analgesic tolerance
Negative_regulation (inhibition) of NR2B associated with analgesic, tolerance and opioid
7) Confidence 0.50 Published 2008 Journal Mol Brain Section Body Doc Link PMC2546399 Disease Relevance 0.07 Pain Relevance 1.98
Semi-quantitative RT-PCR studies on striatal tissue in the oldest age group confirmed the significant decrease in NR2A and also showed a decrease in NR2B.
Negative_regulation (decrease) of NR2B
8) Confidence 0.47 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.14 Pain Relevance 0.47
Inhibition of NMDA NR2B functions in the ACC by local microinjection of pharmacological NR2B antagonists or NR2B siRNA manipulation significantly reduced fear memory [16], suggesting that cortical NMDA receptor NR2B subunit also contribute to fear memory formation.


Negative_regulation (Inhibition) of NMDA NR2B associated with nmda receptor, antagonist, anxiety disorder and anterior cingulate cortex
9) Confidence 0.47 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.77 Pain Relevance 0.52
In this study, Ro 256981, an antagonist of the NMDA receptor subunit NR2B, was used to reduce the expression of analgesic tolerance to morphine.
Negative_regulation (antagonist) of NR2B associated with analgesic, nmda receptor, antagonist, tolerance and morphine
10) Confidence 0.42 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2546399 Disease Relevance 0.16 Pain Relevance 1.41
This study suggests that selective inhibition of NMDA NR2B receptors may prove useful in combating the development of analgesic tolerance to morphine and proposes a novel role for the ACC in opioid tolerance and morphine induced changes in synaptic plasticity.



Negative_regulation (inhibition) of NMDA NR2B in ACC associated with analgesic, tolerance, opioid, anterior cingulate cortex and morphine
11) Confidence 0.42 Published 2008 Journal Mol Brain Section Abstract Doc Link PMC2546399 Disease Relevance 0.08 Pain Relevance 1.58
We also show for the first time that i.t. injection of pSM2 (pShag Magic version 2)-grin2b (coding for an short-hairpin RNA to the NR2B subunit of the NMDAR) resulted in a dose-dependent decrease in the NR2B protein and blockade of hyperalgesia induced by activation of the mGluR1/5 in (S)-3,5-DHPG-treated mice.
Negative_regulation (decrease) of NR2B associated with hyperalgesia
12) Confidence 0.42 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17405869 Disease Relevance 0.34 Pain Relevance 0.66
This suggests that selective inhibition of NR2A/B containing receptors would be effective at reversing pain under conditions of disinhibition.


Negative_regulation (inhibition) of NR2A/B associated with pain
13) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.10 Pain Relevance 0.42
Whole-cell patch clamp recordings revealed that Gentiopicroside significantly reduced NR2B receptors mediated postsynaptic currents in the ACC.
Negative_regulation (reduced) of NR2B in ACC associated with anterior cingulate cortex
14) Confidence 0.41 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18410946 Disease Relevance 0.56 Pain Relevance 1.36
In the dorsal horn of KO mice, the amounts of NR2A and NR2B were decreased by 55% (P < 0.01) and 56% (P < 0.01), respectively, compared to those in WT mice.
Negative_regulation (decreased) of NR2B in dorsal horn associated with targeted disruption and dorsal horn
15) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.33 Pain Relevance 0.36
In the cortex of KO mice, the amounts of NR2A and NR2B were reduced by 60% (P < 0.01) and 58% (P < 0.01), respectively, compared to those in WT mice.
Negative_regulation (reduced) of NR2B in cortex associated with targeted disruption
16) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.41 Pain Relevance 0.45
Clinical considerations for developing NR2B agonists as memory enhancers or antagonists as pain killers
Negative_regulation (developing) of NR2B associated with pain, antagonist and agonist
17) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.71 Pain Relevance 0.66
A relatively selective NR1/NR2A antagonist, NVP-AAM077 (NVP) was developed recently and found to have more than 100-fold preferential blockade of NR1/NR2A vs NR1/NR2B [10].
Negative_regulation (blockade) of NR2B associated with antagonist
18) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.29 Pain Relevance 0.46
If NVP is non-selective, that is, inhibiting NR2B, we then expected that the ifenprodil-sensitive component will be significantly smaller in the presence of NVP.
Negative_regulation (inhibiting) of NR2B
19) Confidence 0.39 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0 Pain Relevance 0.21
In this study, we examined the antinociceptive and motor effects of cone snail venom-derived peptides, conantokins G and T (conG and conT), which are selective inhibitors of the NR2B or NR2A and NR2B subtypes of the NMDA receptor, respectively.
Negative_regulation (inhibitors) of NR2B associated with nmda receptor and antinociceptive
20) Confidence 0.37 Published 2003 Journal Pain Section Abstract Doc Link 12507705 Disease Relevance 0.51 Pain Relevance 0.59

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