INT107585

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Context Info
Confidence 0.71
First Reported 2002
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 35
Total Number 47
Disease Relevance 26.44
Pain Relevance 14.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCR2) plasma membrane (CCR2) cytoplasm (CCR2)
signal transducer activity (CCR2)
Anatomy Link Frequency
monocytes 8
blood 4
plasma 2
lymphocytes 2
T cells 2
CCR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 1008 100.00 Very High Very High Very High
Arthritis 154 100.00 Very High Very High Very High
rheumatoid arthritis 788 99.84 Very High Very High Very High
Multiple sclerosis 27 99.32 Very High Very High Very High
dorsal root ganglion 4 99.12 Very High Very High Very High
Neuritis 8 97.76 Very High Very High Very High
Morphine 6 97.26 Very High Very High Very High
Inflammation 752 97.08 Very High Very High Very High
Angina 2 94.72 High High
Chronic pancreatitis 130 94.64 High High
Disease Link Frequency Relevance Heat
Arthritis 81 100.00 Very High Very High Very High
Rheumatoid Arthritis 807 99.84 Very High Very High Very High
Injury 10 99.46 Very High Very High Very High
Infection 157 99.36 Very High Very High Very High
Demyelinating Disease 28 99.32 Very High Very High Very High
Syndrome 86 99.24 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 172 99.16 Very High Very High Very High
Adenocarcinoma 1170 99.12 Very High Very High Very High
Ganglion Cysts 5 99.12 Very High Very High Very High
Disease 211 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR.
Gene_expression (expression) of CCR2b in NHA associated with chemokine and morphine
1) Confidence 0.71 Published 2005 Journal Clin. Immunol. Section Abstract Doc Link 15893700 Disease Relevance 0 Pain Relevance 0.86
Furthermore, RA monocytes/macrophages express CC chemokine receptors such as CCR1, CCR2, CCR3 and CCR5 [14], illustrating their broad profile of chemokine receptor expression.
Gene_expression (express) of CCR2 in macrophages associated with chemokine and rheumatoid arthritis
2) Confidence 0.69 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 0.93 Pain Relevance 0.69
Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK.
Gene_expression (expression) of CCR2 in monocyte associated with chemokine
3) Confidence 0.68 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.33 Pain Relevance 0.22
For example, in cells co-expressing the CCR2b and CCR5 chemokine receptors CCR5-specific ligands that are unable to compete for MCP-1 binding on cells expressing CCR2b alone, and hence presumable do not bind directly to CCR2b, were able to prevent efficiently MCP-1 binding when the two receptors were co-expressed [26].
Gene_expression (expressing) of CCR2b associated with chemokine
4) Confidence 0.62 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.15
Four chemokine receptors (CCR2b, CCR3, CCR4 and CCR6) could not be detected in RA samples or non-RA samples under our conditions.
Neg (not) Gene_expression (detected) of CCR2b associated with chemokine and rheumatoid arthritis
5) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065316 Disease Relevance 1.22 Pain Relevance 0.73
For example, in cells co-expressing the CCR2b and CCR5 chemokine receptors CCR5-specific ligands that are unable to compete for MCP-1 binding on cells expressing CCR2b alone, and hence presumable do not bind directly to CCR2b, were able to prevent efficiently MCP-1 binding when the two receptors were co-expressed [26].
Gene_expression (expressing) of CCR2b associated with chemokine
6) Confidence 0.48 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.18
Studies on heterodimerization between the CCR2b and CCR5 chemokine receptors have demonstrated the ability of CCR5-specific ligands, that are unable to compete for the binding of the CCR2 selective ligand MCP-1 (monocyte chemoattractant protein 1) on cells expressing CCR2b alone, to prevent efficiently MCP-1 binding when the two receptors are co-expressed [26].
Gene_expression (expressing) of CCR2b in monocyte associated with chemokine
7) Confidence 0.48 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0 Pain Relevance 0.15
We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients.
Gene_expression (expression) of CCR2 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
8) Confidence 0.47 Published 2004 Journal Eur. J. Neurol. Section Abstract Doc Link 15257681 Disease Relevance 0.83 Pain Relevance 0.56
Although MDCs displayed unchanged levels of CCR2, PDCs expressed decreased levels of CCR2 both pre and post surgery (pre: median 437, post: median 441) compared to controls (median 602) (Figure 5A).


Neg (unchanged) Gene_expression (levels) of CCR2
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.63 Pain Relevance 0.40
The expression of CCR2 and CCR6 by PDCs and MDCs did also match the profile found in PDAC, but only CCR2 (p?
Gene_expression (expression) of CCR2 associated with adenocarcinoma
10) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.47 Pain Relevance 0.56
Although MDCs displayed unchanged levels of CCR2, PDCs expressed decreased levels of CCR2 both pre and post surgery (pre: median 437, post: median 441) compared to controls (median 602) (Figure 5A).


Gene_expression (expressed) of CCR2
11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.66 Pain Relevance 0.41
Blood PDCs express many different chemokine receptors including CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 [40], whereas MDC express CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8 [19], [20], [21].
Gene_expression (express) of CCR2 in Blood associated with chemokine
12) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.28 Pain Relevance 0.14
Moreover, patients with high CCR2 levels on their PDCs (range 437–581) had a better clinical outcome (p?
Gene_expression (levels) of CCR2
13) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.46 Pain Relevance 0
Significantly increased levels of CCR6 were found on MDCs pre and post surgery (pre: median 380, post: median 398) compared to healthy individuals (median 255) (Figure 5C), and for CCR7 (pre: median 1.6%, post: median 1.6%, control: median 0%) (Figure 5D) but not for CCR2 (Figure 5A).
Neg (not) Spec (found) Gene_expression (found) of CCR2
14) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.23 Pain Relevance 0.17
Of note, we did see a down modulation of CCR2, and CCR6 expression to almost undetectable levels compared to CCR2 and CCR6 levels seen on ex vivo DCs from PDAC patients, independent of the treatment of the DCs, i.e. untreated or activated by TLR ligands.
Gene_expression (expression) of CCR2 associated with adenocarcinoma
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.36 Pain Relevance 0.04
Monocyte chemoattractant protein 1 and chemokine receptor CCR2 productions in Guillain-Barré syndrome and experimental autoimmune neuritis.
Gene_expression (productions) of CCR2 in Monocyte associated with chemokine, experimental autoimmune neuritis, syndrome and neuritis
16) Confidence 0.37 Published 2003 Journal J. Neuroimmunol. Section Title Doc Link 12507779 Disease Relevance 1.06 Pain Relevance 0.54
They have a broad array of functional T1- and T2-associated chemokine receptors, but also express high levels of CCR2 and CCR8 which allow resting as well as activated Th IL-10 cells to display a significant migratory capacity to CCL2 and CCL1 [46].


Gene_expression (express) of CCR2 associated with chemokine
17) Confidence 0.35 Published 2002 Journal BMC Dermatol Section Body Doc Link PMC122084 Disease Relevance 0.36 Pain Relevance 0.21
Moreover, the sustained expression of ICOSL on both MDCs and PDCs and CCR2 on PDCs was a strong indicator of patient survival.
Gene_expression (expression) of CCR2
18) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 1.00 Pain Relevance 0.14
Blood PDCs express many different chemokine receptors including CCR2, CCR5, CCR6, CCR7, CXCR3, and CXCR4 [40], whereas MDC express CCR1, CCR2, CCR3, CCR5, CCR6, CCR7 and CCR8 [19], [20], [21].
Gene_expression (express) of CCR2 in Blood associated with chemokine
19) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.23 Pain Relevance 0.14
Our results indicate that the PDAC patients with the best clinical outcome retained high expression of ICOSL on both MDCs and PDCs and CCR2 on PDCs, which indicate that the DCs were less affected by the tumor.
Gene_expression (expression) of CCR2 associated with adenocarcinoma and cancer
20) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.67 Pain Relevance 0.08

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