INT107597

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.35
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Patient controlled alalgesia 21 100.00 Very High Very High Very High
spinal inflammation 21 100.00 Very High Very High Very High
Pain management 8 100.00 Very High Very High Very High
Pain score 6 98.56 Very High Very High Very High
Pain 33 89.92 High High
Analgesic 5 88.00 High High
cytokine 9 83.72 Quite High
Perioperative pain 17 78.16 Quite High
Morphine 15 69.44 Quite High
Osteoarthritis 45 52.48 Quite High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 20 100.00 Very High Very High Very High
Pain 49 99.98 Very High Very High Very High
Calcification 138 98.96 Very High Very High Very High
Heterotopic Ossification 4 79.20 Quite High
Post Operative Pain 18 78.16 Quite High
Obesity 6 77.00 Quite High
Disease 24 75.84 Quite High
Rheumatic Diseases 4 74.88 Quite High
Osteoporosis 12 74.24 Quite High
Insulin Resistance 3 68.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPP1 and PPi deficiency states are linked to accelerated chondrogenesis
NPP1 Binding (linked) of
1) Confidence 0.37 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.39 Pain Relevance 0.04
To elucidate the role of NPPS in the pathogenesis of AS, we examined serum NPPS activity and the possible association of the NPPS gene with AS.
NPPS Binding (association) of associated with spinal inflammation
2) Confidence 0.37 Published 2003 Journal Rheumatology (Oxford) Section Abstract Doc Link 12509614 Disease Relevance 1.09 Pain Relevance 0.73
The potential roles in calcification of these alternative effects of NPP1, and of other NPP1 interactions with nucleotide-hydrolyzing ecto-ezymes, remain to be determined.
NPP1 Binding (interactions) of associated with calcification
3) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.44 Pain Relevance 0.03
In humans, 18 of 23 kindreds demonstrated homozygosity or compound heterozygosity for mutations of NPP1 in association with generalized arterial calcification of infancy (GACI, IIAC, MIM# 208000) [23, 24].
NPP1 Binding (association) of associated with calcification
4) Confidence 0.36 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.61 Pain Relevance 0
We determined serum NPPS activity using high-performance liquid chromatography and examined the association between AS and NPPS using single nucleotide polymorphisms (SNPs) of the NPPS gene.
NPPS Spec (examined) Binding (association) of
5) Confidence 0.32 Published 2003 Journal Rheumatology (Oxford) Section Body Doc Link 12509614 Disease Relevance 0.09 Pain Relevance 0
Results: Pain management with PCA after DIEP flap breast reconstruction was uniformly controlled.
PCA Binding (management) of associated with patient controlled alalgesia and pain management
6) Confidence 0.04 Published 2010 Journal Eplasty Section Abstract Doc Link PMC2941188 Disease Relevance 0.73 Pain Relevance 1.43

General Comments

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