INT107599

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Context Info
Confidence 0.51
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.02
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

generation of precursor metabolites and energy (Enpp1) extracellular space (Enpp1) plasma membrane (Enpp1)
Anatomy Link Frequency
face 1
Enpp1 (Mus musculus)
Pain Link Frequency Relevance Heat
spinal inflammation 22 99.48 Very High Very High Very High
antagonist 1 97.48 Very High Very High Very High
Inflammation 90 85.04 High High
cINOD 4 84.96 Quite High
cytokine 42 83.72 Quite High
dexamethasone 36 81.16 Quite High
Osteoarthritis 60 63.28 Quite High
addiction 2 49.56 Quite Low
Pain 5 48.04 Quite Low
depression 8 42.00 Quite Low
Disease Link Frequency Relevance Heat
Anaphylaxis 66 100.00 Very High Very High Very High
Seronegative Spondarthritis 20 99.48 Very High Very High Very High
Targeted Disruption 5 99.44 Very High Very High Very High
Calcification 184 97.16 Very High Very High Very High
Rheumatic Diseases 4 96.24 Very High Very High Very High
Osteoporosis 16 93.60 High High
Heterotopic Ossification 4 93.08 High High
Syndrome 6 92.24 High High
Hypersensitivity 130 91.88 High High
Hypophosphatasia 48 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Serum NPPS activity in AS patients was significantly decreased compared with the controls (P < 0.0001).
Negative_regulation (decreased) of NPPS
1) Confidence 0.51 Published 2003 Journal Rheumatology (Oxford) Section Body Doc Link 12509614 Disease Relevance 0.09 Pain Relevance 0
Many of these NPP1 mutations, which are mostly in the nuclease-like and catalytic, domains, but also reported in the somatomedin B-like domain, have been established to impair NPP1 catalytic activity [23, 24].
Negative_regulation (impair) of NPP1
2) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.45 Pain Relevance 0
The MVs, are enriched in NPP1 and TNAP, whose catalytic domains are predominantly exposed at the external face of MVs.
Negative_regulation (enriched) of NPP1 in face
3) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.39 Pain Relevance 0
NPP1 and PPi deficiency states are linked to accelerated chondrogenesis
Negative_regulation (deficiency) of NPP1
4) Confidence 0.43 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.39 Pain Relevance 0.04
Decrease in serum nucleotide pyrophosphatase activity in ankylosing spondylitis.
Negative_regulation (Decrease) of serum nucleotide pyrophosphatase associated with spinal inflammation
5) Confidence 0.37 Published 2003 Journal Rheumatology (Oxford) Section Title Doc Link 12509614 Disease Relevance 1.11 Pain Relevance 0.72
Consistent with the apparent co-dependent function of ANK and NPP1 to raise extracellular PPi [34] is the remarkable similarity in the consequences of deficient ANK and PC-1 function in vivo.
Negative_regulation (deficient) of PC-1
6) Confidence 0.19 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.93 Pain Relevance 0.06
Indeed, it has been shown in mice that inactivation of the Pc-1 gene in TNAP-knock-out mice allows to restore the normal bone phenotype [17].
Negative_regulation (inactivation) of Pc-1 associated with targeted disruption
7) Confidence 0.13 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2164941 Disease Relevance 0.66 Pain Relevance 0.07
The effect increased to 57.4% inhibition of the PCA reaction after pre-treatment for 2 h.
Negative_regulation (inhibition) of PCA associated with anaphylaxis
8) Confidence 0.07 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 0.77 Pain Relevance 0
Moreover, the PCA inhibition was strictly dose-dependent, which confirmed the pharmacologically relevant dose-response correlation of beta-escin with the reduction of symptoms.
Negative_regulation (inhibition) of PCA associated with anaphylaxis
9) Confidence 0.05 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 1.25 Pain Relevance 0.35

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