INT107601

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Context Info
Confidence 0.25
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.66
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
OPLL 1
OPLL (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 13 94.88 High High
antagonist 6 36.44 Quite Low
agonist 4 31.16 Quite Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Osteoarthritis 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heterotopic Ossification 32 97.20 Very High Very High Very High
Seronegative Spondarthritis 10 94.88 High High
Disease 14 88.96 High High
Rheumatic Diseases 2 88.52 High High
Spinal Cord Diseases 4 84.64 Quite High
Osteoporosis 16 5.00 Very Low Very Low Very Low
Metabolic Disorder 6 5.00 Very Low Very Low Very Low
Rickets 4 5.00 Very Low Very Low Very Low
Low Back Pain 4 5.00 Very Low Very Low Very Low
Genetic Predisposition To Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The “G” allele in the Ser87Ser (A/G) polymorphism promotes the extent of OPLL, but does not promote an increased susceptibility to OPLL, whereas the “A” allele in the Ser87Ser (A/G) polymorphism restricts ectopic ossification at least in Chinese subjects.
Neg (not) Positive_regulation (increased) of OPLL associated with heterotopic ossification
1) Confidence 0.25 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.25 Pain Relevance 0
The histopathologic features of OPLL are characterized by the abnormal expression of BMP-2, TGF-?
Positive_regulation (features) of OPLL
2) Confidence 0.25 Published 2008 Journal Eur Spine J Section Body Doc Link PMC2443260 Disease Relevance 0.33 Pain Relevance 0
Recently, nucleotide pyrophosphatase (NPPS) was implicated in the aetiology of OPLL: an Npps mutation was found to cause OPLL in mice, and an association between a polymorphism of the human NPPS gene and OPLL was identified.
Positive_regulation (cause) of OPLL in OPLL
3) Confidence 0.16 Published 2003 Journal Rheumatology (Oxford) Section Abstract Doc Link 12509614 Disease Relevance 1.08 Pain Relevance 0.72

General Comments

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