INT107604

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Context Info
Confidence 0.07
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.08
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (NALCN)
Anatomy Link Frequency
pore 1
peripheral nervous systems 1
NALCN (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 12 100.00 Very High Very High Very High
gABA 3 98.20 Very High Very High Very High
Calcium channel 26 96.84 Very High Very High Very High
agonist 24 95.76 Very High Very High Very High
potassium channel 2 87.52 High High
Glutamate receptor 1 87.32 High High
antagonist 3 82.80 Quite High
GABAergic 1 76.64 Quite High
Eae 1 71.76 Quite High
depression 3 54.80 Quite High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 4 98.68 Very High Very High Very High
Poisoning 44 89.88 High High
Shellfish Poisoning 104 89.68 High High
Syndrome 6 81.48 Quite High
Ciguatera Poisoning 10 77.84 Quite High
Depression 3 54.80 Quite High
Death 12 43.96 Quite Low
Anxiety Disorder 3 36.24 Quite Low
Pain 3 30.56 Quite Low
Cognitive Disorder 1 30.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although a bindings site for steroids at GABA(A) receptors is still a matter of debate, meanwhile there is also evidence that steroids interact allosterically with ligand-gated ion channels at the receptor membrane interface.
ion Binding (interact) of associated with gaba
1) Confidence 0.07 Published 2003 Journal Psychoneuroendocrinology Section Abstract Doc Link 12510009 Disease Relevance 0.05 Pain Relevance 0.32
Ion specificity is determined by a pore consensus sequence [T/S] × [D/E] × W in voltage gated Calcium channels [22].
Ion Binding (specificity) of in pore associated with calcium channel
2) Confidence 0.00 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC184451 Disease Relevance 0 Pain Relevance 0.08
Nicotinic acetylcholine receptors (nAChRs) belong to a family of ligand-gated ion channels that bind neurotransmitter molecules [1,2], and mediate fast signal transmission at synapses throughout the central and peripheral nervous systems.
ion Binding (bind) of in peripheral nervous systems associated with neurotransmitter
3) Confidence 0.00 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1584325 Disease Relevance 0 Pain Relevance 0.12
It is known that most dinoflagellate toxins are neurotoxins, which interact with the specific receptors associated with neurotransmitter receptors, or voltage-sensitive ion channels (Figure 1), resulting in the observed neurotoxicity [12].
ion Binding (interact) of associated with neurotransmitter and drug induced neurotoxicity
4) Confidence 0.00 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 1.39 Pain Relevance 0.09
The neurotoxicity of dinoflagellate toxins is mediated by diverse, highly specific interactions with ion channels involved in neurotransmission (Figure 1).
ion Binding (interactions) of associated with drug induced neurotoxicity
5) Confidence 0.00 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 1.63 Pain Relevance 0.03

General Comments

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