INT107605

Context Info Confidence 0.64 First Reported 2002 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 26 Total Number 29 Disease Relevance 25.88 Pain Relevance 4.49

cytoplasm (MMP14)

Anatomy Link Frequency colon 2 skeleton 2 platelet 2 lymph node 1 basement membrane 1 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 409 100.00 chemokine 114 99.04 Adalimumab 4 98.68 qutenza 5 98.62 cytokine 150 96.96 Inflammatory response 12 96.28 Inflammation 272 90.08 methotrexate 2 87.00 Potency 12 83.08 Multiple sclerosis 180 79.44

Disease Link Frequency Relevance Heat Prostate Cancer 406 99.96 Adenocarcinoma 79 99.84 Shock 8 99.82 Metastasis 283 99.80 Chondrosarcoma 12 99.52 Osteolysis 36 99.28 Cancer 448 99.08 Osteogenic Sarcomas 4 99.06 Aggression 9 99.04 Death 36 98.96

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MMP-1 mRNA expression was evaluated by Northern blotting.

Gene_expression (expression) of MMP-1

1) Confidence 0.64 Published 2003 Journal Pancreatology Section Abstract Doc Link 14526152 Disease Relevance 0.21 Pain Relevance 0.31

Expression of MMP14 by adenocarcinoma cells has been previously established by in situ hybridization, which is consistent with its clustering within the “Adeno 1” cluster.

Gene_expression (Expression) of MMP14 associated with adenocarcinoma

2) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 0.80 Pain Relevance 0.05

HT-1080 cells, which express MMP-14 and MMP-2, were used to assess the effect on MMP-2 activity by the selective inhibition of endogenous MMP-14 by DX-2400.

Gene_expression (express) of MMP-14 in HT-1080

3) Confidence 0.39 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.51 Pain Relevance 0.17

-driven matrix metalloproteinase-1 (MMP-1) and MMP-13 gene expression in SW-1353 chondrosarcoma cells.

Gene_expression (expression) of matrix metalloproteinase-1 associated with chondrosarcoma and metalloproteinase

4) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656243 Disease Relevance 0.10 Pain Relevance 0.12

In adalimumab recipient, radiographic progression is also controlled and serum levels of matrix metalloproteinase-1(MMP-1) and MMP-3 decrease.

Gene_expression (levels) of matrix metalloproteinase-1 associated with metalloproteinase and adalimumab

5) Confidence 0.38 Published 2002 Journal Nippon Rinsho Section Abstract Doc Link 12510366 Disease Relevance 0.40 Pain Relevance 0.34

The expression of MMP-14 and MMP-2 correlates with the depth of tumor and vascular invasion in human colon cancer [110].

Gene_expression (expression) of MMP-14 in colon associated with cancer and colon cancer

6) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 2.18 Pain Relevance 0.09

MMP-14 expression is elevated in various human carcinomas including uterine cervix [93], stomach [94], lung [95–97], breast [98], colon [99], head and neck [100], malignant brain tumors [101], and melanoma [102].

Gene_expression (expression) of MMP-14 in colon associated with malignant neoplastic disease, carcinoma, skin cancer and brain tumor

7) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.60 Pain Relevance 0.15

High MMP-14 expression is associated with early death of patients with supraglottic carcinoma [105], colorectal carcinoma [106], or breast cancer [107] and is correlated with lymph node metastases, progression, invasion, poor clinical stage, larger tumor size, and with increasing tumor stage [108, 109].

Gene_expression (expression) of MMP-14 in lymph node associated with cancer, breast cancer, colon cancer, carcinoma, metastasis and death

8) Confidence 0.31 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 2.08 Pain Relevance 0.10

Compared with controls, tibiae injected with LNCaP cells overexpressing mt1-mmp showed increased osteolysis (as demonstrated by radiography and histomorphometry) and enhanced intraosseous tumour growth.

Gene_expression (overexpressing) of mt1-mmp associated with cancer and osteolysis

9) Confidence 0.22 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.26 Pain Relevance 0

In contrast, mt1-mmp downregulation in high-expressing mt1-mmp DU145 prostate cancer cells led to diminished intraosseous tumour growth and a mixed bone reaction, in which osteosclerotic responses predominated 31.

Gene_expression (expressing) of mt1-mmp associated with cancer and prostate cancer

10) Confidence 0.22 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.08 Pain Relevance 0

Alternatively, the bone microenvironment might induce the expression of mt1-mmp in prostate cancer cells after their arrival in the marrow.

Gene_expression (expression) of mt1-mmp associated with prostate cancer

11) Confidence 0.22 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.40 Pain Relevance 0

We overexpressed mt1-mmp in LNCaP human prostate cancer cells (which have baseline non-detectable expression of the protease), while its expression was attenuated in DU145 cells (which have baseline high mt1-mmp expression) using small interfering rna.

Gene_expression (overexpressed) of mt1-mmp associated with prostate cancer

12) Confidence 0.22 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.36 Pain Relevance 0

That finding, together with a uniform and strong mt1-mmp expression observed in all cases of prostate cancer bone metastases analyzed 31, suggests the existence of a selective process in which mt1-mmp–expressing prostate cancer cells may have more tendency to metastasize to skeleton.

Gene_expression (expression) of mt1-mmp in skeleton associated with prostate cancer and metastasis

13) Confidence 0.22 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.65 Pain Relevance 0

That finding, together with a uniform and strong mt1-mmp expression observed in all cases of prostate cancer bone metastases analyzed 31, suggests the existence of a selective process in which mt1-mmp–expressing prostate cancer cells may have more tendency to metastasize to skeleton.

Gene_expression (expressing) of mt1-mmp in skeleton associated with prostate cancer and metastasis

14) Confidence 0.22 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.48 Pain Relevance 0

Gene filter data from two patients showed similar expression pattern of collagen type 1 (alpha 2), Collagen type III (alpha 1), fibronectin 1, Matrix metalloproteinase-1 (MMP-1), Transforming Growth Factor beta-1 (TGF-?

Gene_expression (expression) of Matrix metalloproteinase-1 associated with metalloproteinase

15) Confidence 0.22 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 0.58 Pain Relevance 0.10

Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes.

Gene_expression (expression) of matrix metalloproteinase-1 in keratinocytes associated with qutenza, shock and metalloproteinase

16) Confidence 0.20 Published 2007 Journal J. Invest. Dermatol. Section Title Doc Link 17508023 Disease Relevance 0.50 Pain Relevance 0.57

We overexpressed mt1-mmp in LNCaP human prostate cancer cells (which have baseline non-detectable expression of the protease), while its expression was attenuated in DU145 cells (which have baseline high mt1-mmp expression) using small interfering rna.

Gene_expression (expression) of mt1-mmp associated with prostate cancer

17) Confidence 0.19 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.37 Pain Relevance 0

In prostate cancer, mt1-mmp expression correlates with a more aggressive behaviour and has been shown to promote invasion and metastasis 27–29.

Gene_expression (expression) of mt1-mmp associated with aggression, prostate cancer and metastasis

18) Confidence 0.19 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.55 Pain Relevance 0

It is now known that, for example, low concentrations of timp-2 can promote activation of pro-mmp-2 through a mechanism in which timp-2 acts as a linker between the pro-mmp-2 zymogen and mt1-mmp at the cell surface.

Gene_expression (zymogen) of mt1-mmp

19) Confidence 0.19 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0.05 Pain Relevance 0

stimulation (MMP-1, MMP-3, MMP-9, and MMP-13) as well as those that are constitutively expressed in these cells (MMP-2 and MMP-14).

Gene_expression (expressed) of MMP-14

20) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0.13

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