INT107607

Context Info Confidence 0.37 First Reported 2002 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 10 Total Number 12 Disease Relevance 6.05 Pain Relevance 1.83

cytoplasm (MMP14)

Anatomy Link Frequency spinal 1 HT-1080 1 decidua 1 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 210 100.00 Adalimumab 4 98.48 Dismenorea 3 98.32 spinal stenosis 44 96.80 Potency 11 89.60 methotrexate 2 86.60 Inflammation 80 75.60 Pain 15 73.60 Arthritis 8 72.48 cytokine 18 67.44

Disease Link Frequency Relevance Heat Cancer 167 99.12 Prostate Cancer 73 98.64 Rheumatoid Arthritis 39 98.40 Dysmenorrhea 3 98.32 Spinal Stenosis 46 96.80 Osteolysis 8 95.64 Hypercalcemia 20 95.32 Infection 30 92.88 Adhesions 18 91.96 Hypertrophy 12 90.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In adalimumab recipient, radiographic progression is also controlled and serum levels of matrix metalloproteinase-1(MMP-1) and MMP-3 decrease.

Negative_regulation (decrease) of matrix metalloproteinase-1 associated with metalloproteinase and adalimumab

1) Confidence 0.37 Published 2002 Journal Nippon Rinsho Section Abstract Doc Link 12510366 Disease Relevance 0.40 Pain Relevance 0.34

DX-2400 blocked proMMP-2 processing, whereas a polyclonal rabbit anti–MMP-14 antibody, which does not inhibit MMP-14 activity, failed to inhibit proMMP-2 activation.

Negative_regulation (inhibit) of MMP-14

2) Confidence 0.30 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.51 Pain Relevance 0.10

HT-1080 cells, which express MMP-14 and MMP-2, were used to assess the effect on MMP-2 activity by the selective inhibition of endogenous MMP-14 by DX-2400.

Negative_regulation (inhibition) of MMP-14 in HT-1080

3) Confidence 0.26 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.56 Pain Relevance 0.16

We found that in media conditioned by decidua, following the establishment of uterine contractions, matrix metalloproteinase-2 (MMP-2) activity is increased while the protein tissue inhibitors of matrix metalloproteinase-1 (TIMP-1) level is decreased.

Negative_regulation (inhibitors) of matrix metalloproteinase-1 in decidua associated with metalloproteinase and dismenorea

4) Confidence 0.22 Published 2003 Journal Mol. Hum. Reprod. Section Abstract Doc Link 12771238 Disease Relevance 0.34 Pain Relevance 0.39

Combining our human antibody phage display library with automated selection and screening strategies (Figure 1) [28], we have identified highly selective antibody-based MMP inhibitor of MMP-14 (DX-2400).

Negative_regulation (inhibitor) of MMP-14

5) Confidence 0.19 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 0.44 Pain Relevance 0.19

In contrast, mt1-mmp downregulation in high-expressing mt1-mmp DU145 prostate cancer cells led to diminished intraosseous tumour growth and a mixed bone reaction, in which osteosclerotic responses predominated 31.

Negative_regulation (downregulation) of mt1-mmp associated with cancer and prostate cancer

6) Confidence 0.12 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.14 Pain Relevance 0

Conversely, high levels of timp-2 relative to mt1-mmp would inhibit activation by blocking all free mt1-mmp molecules.

Negative_regulation (blocking) of mt1-mmp

7) Confidence 0.12 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 0.23 Pain Relevance 0

Agouron developed prinomastat (AG3340) [114], a MMP inhibitor with a Ki value in the picomolar range for the inhibition of MMP-2, MMP-9, MMP-13 and MMP-14, with lower activity against MMP-1 and MMP-7 [115].

Negative_regulation (inhibition) of MMP-14

8) Confidence 0.09 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.59 Pain Relevance 0.15

MMP-14 was strongly down-regulated, when compared with healthy controls.

Negative_regulation (regulated) of MMP-14

9) Confidence 0.07 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.51 Pain Relevance 0.14

1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and TIMP-2 in hypertrophied ligamentum flavum of patients with lumbar spinal stenosis compared to patients with lumbar disc herniation.

Negative_regulation (inhibitor) of matrix metalloproteinase-1 in spinal associated with metalloproteinase and spinal stenosis

10) Confidence 0.05 Published 2007 Journal Asian Spine Journal Section Body Doc Link PMC2857497 Disease Relevance 0.80 Pain Relevance 0.20

1), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and TIMP-2 were measured by enzyme-linked immunosorbent assay.

Negative_regulation (inhibitor) of matrix metalloproteinase-1 associated with metalloproteinase

11) Confidence 0.04 Published 2007 Journal Asian Spine Journal Section Abstract Doc Link PMC2857497 Disease Relevance 0.36 Pain Relevance 0.16

This is consistent with previous reports that found that MUC1 shedding was sensitive to MMP-14 depletion in endometrial cells [24].

Negative_regulation (depletion) of MMP-14

12) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.17 Pain Relevance 0

General Comments

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