INT107618

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Context Info
Confidence 0.41
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.82
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGER3) cell death (PTGER3) plasma membrane (PTGER3)
biological_process (PTGER3) signal transducer activity (PTGER3)
Anatomy Link Frequency
uterine 3
endothelial cells 1
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 98.70 Very High Very High Very High
Opioid 1 98.40 Very High Very High Very High
dexamethasone 2 93.68 High High
Paracetamol 2 92.96 High High
Cannabinoid receptor 9 84.00 Quite High
agonist 56 82.20 Quite High
Hippocampus 4 81.52 Quite High
cINOD 39 80.88 Quite High
long-term potentiation 1 60.24 Quite High
Potency 8 44.28 Quite Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 216 99.92 Very High Very High Very High
Bordatella Infection 8 83.28 Quite High
Neuroblastoma 12 82.52 Quite High
Disorders Of Creatine Metabolism 1 79.60 Quite High
Colon Cancer 131 79.20 Quite High
Phosphate Metabolism Disorders 55 68.96 Quite High
Malignant Neoplastic Disease 2 50.80 Quite High
Muscle Weakness 1 48.60 Quite Low
Disease 15 47.76 Quite Low
Cancer 72 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prostaglandin E2 receptor subtype 3 (PTGER3 or EP3) is a G-protein-coupled receptor activated by prostaglandin E2 that was down regulated in uterine fibroids.
Positive_regulation (activated) of Prostaglandin E2 receptor subtype 3 in uterine associated with uterine fibroids
1) Confidence 0.41 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.43 Pain Relevance 0
It means that IL-1beta-triggered-PGE2 biosynthesis in endothelial cells is probably regulated by induction of both COX-2 and PGE-S.
Positive_regulation (induction) of PGE-S in endothelial cells
2) Confidence 0.37 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 12512699 Disease Relevance 0 Pain Relevance 0.13
The induction of endothelial PGE-S and COX-2 appeared to be and their transcripts were induced as fast as one might expect from immediate early genes.
Positive_regulation (induction) of PGE-S
3) Confidence 0.33 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 12512699 Disease Relevance 0 Pain Relevance 0.14
In particular, the clear effect of the highly specific reagent PTX strongly argued for the involvement of the Gi-coupled prostanoid receptor EP3.


Positive_regulation (coupled) of EP3
4) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.21
Prostaglandin E2 receptor subtype 3 (PTGER3 or EP3) is a G-protein-coupled receptor activated by prostaglandin E2 that was down regulated in uterine fibroids.
Positive_regulation (activated) of PTGER3 in uterine associated with uterine fibroids
5) Confidence 0.28 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.42 Pain Relevance 0
Prostaglandin E2 receptor subtype 3 (PTGER3 or EP3) is a G-protein-coupled receptor activated by prostaglandin E2 that was down regulated in uterine fibroids.
Positive_regulation (activated) of EP3 in uterine associated with uterine fibroids
6) Confidence 0.28 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.42 Pain Relevance 0
Remarkably, only the bona fide Gi-coupled species EP3 subtypes 7 and 8 (the downstream coupling pattern to heterotimeric G-proteins by subtype 3 is as yet unknown) [15,36-39] were induced in response to serum removal, in agreement with the current findings pointing to a major role for these receptors in PGE2 dependent cell proliferation as monitored here in the absence of serum.


Positive_regulation (induced) of EP3
7) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.19 Pain Relevance 0.08
These studies also found evidence for secretin, prostacyclin, opioid and alpha2-adrenergic receptors In support of this we found significantly high levels of mRNA for Ptgir1, Ptger1, Ptger3, Ptger4, Oprd1, Oprl1 and Adra2b.
Positive_regulation (levels) of Ptger3 associated with opioid
8) Confidence 0.13 Published 2011 Journal BMC Genomics Section Body Doc Link PMC3024950 Disease Relevance 0.08 Pain Relevance 0.14
A significant reduction of systemic PGE-M levels, which were elevated in four out of five pre-treatment periods, was noted (figure 4) (Mann Whitney's exact U-Test: p = 0.016).
Positive_regulation (elevated) of PGE-M
9) Confidence 0.03 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.21 Pain Relevance 0
A blockade of synaptic transmission with either tetrodotoxin or MK-801 plus 6,7-dinitroquinoxaline-2,3-dione (DNQX) for 6 hr increased EP 3 and EP 4 mRNA, whereas high K(+) (90 mM) or 4-aminopyridine enhanced EP 2 and EP 4.
Positive_regulation (increased) of EP 3 associated with tetrodotoxin
10) Confidence 0.01 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16041798 Disease Relevance 0 Pain Relevance 0.32

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