INT107619

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 15.00
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGER3) cell death (PTGER3) plasma membrane (PTGER3)
biological_process (PTGER3) signal transducer activity (PTGER3)
Anatomy Link Frequency
HT-29 7
tail 3
colon 2
muscle 1
articular cartilage 1
PTGER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 129 99.54 Very High Very High Very High
Hippocampus 8 98.72 Very High Very High Very High
Inflammation 288 97.92 Very High Very High Very High
Osteoarthritis 41 97.36 Very High Very High Very High
cINOD 221 96.52 Very High Very High Very High
metalloproteinase 20 95.04 Very High Very High Very High
agonist 476 94.24 High High
antagonist 236 93.36 High High
tetrodotoxin 4 90.56 High High
calcitonin gene related peptide 5 88.16 High High
Disease Link Frequency Relevance Heat
Colon Cancer 1140 100.00 Very High Very High Very High
Apoptosis 639 99.40 Very High Very High Very High
Sarcoma 2 99.16 Very High Very High Very High
Uterine Fibroids 360 99.08 Very High Very High Very High
Hypertrophy 110 98.84 Very High Very High Very High
Rhinitis 80 98.74 Very High Very High Very High
Cancer 444 98.24 Very High Very High Very High
INFLAMMATION 387 97.92 Very High Very High Very High
Colorectal Cancer 36 97.86 Very High Very High Very High
Chronic Sinusitis 120 97.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FP and EP3 receptors are ubiquitously expressed throughout the body and exhibit pleiotropic metabolic responses when stimulated.
Gene_expression (expressed) of EP3 in body
1) Confidence 0.75 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.59 Pain Relevance 0
Due to the fact that both of these responses downstream from these receptors are integral to muscular hypertrophy, we chose to examine if AA supplementation increased the expression of the FP and EP3 receptors.
Gene_expression (expression) of EP3 associated with hypertrophy
2) Confidence 0.75 Published 2007 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2217562 Disease Relevance 0.30 Pain Relevance 0
As shown in Fig. 7B serum withdrawal gradually induced the expression of EP3.
Gene_expression (expression) of EP3 associated with withdrawal
3) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.18
Removal of serum leads to the induction of EP3 expression whereas EP3 was virtually undetectable in cells kept in serum.
Gene_expression (expression) of EP3
4) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.38 Pain Relevance 0.04
We document that HT-29 cells do express the EP3 receptor but EP3 expression appears to be tightly regulated.
Gene_expression (express) of EP3 in HT-29
5) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.39 Pain Relevance 0.04
The results of this analysis, shown in Fig. 7A, evidenced that HT-29 cells express EP1, EP2 and EP4 receptors but no EP3.
Neg (no) Gene_expression (express) of EP3 in HT-29
6) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.07 Pain Relevance 0.24
Importantly, EP3 expression was detectable as early as 24 h after serum removal, that is, precisely the conditions used for cAMP signalling analysis and proliferation assays.
Gene_expression (expression) of EP3
7) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.17
Interestingly, EP3 receptor levels are down regulated in colon cancer mucosa in comparison to healthy tissue [26], indicating that EP3 expression may not be compatible with a high proliferative rate in those cells.
Gene_expression (expression) of EP3 in colon associated with colon cancer
8) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.52 Pain Relevance 0.04
We document that HT-29 cells do express the EP3 receptor but EP3 expression appears to be tightly regulated.
Gene_expression (expression) of EP3 in HT-29
9) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.38 Pain Relevance 0.04
We are intrigued by the possibility that EP3 expression may be generally linked to the proliferative state of the cell and could serve as a lever to finely adjust the proliferative rate of CRC cells.
Gene_expression (expression) of EP3 in lever associated with colon cancer
10) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.54 Pain Relevance 0.03
Expression of the Gi-coupled prostanoid receptor subtype EP3 is growth-dependently regulated in HT-29 cells
Gene_expression (Expression) of Gi-coupled prostanoid receptor subtype EP3 in HT-29
11) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.18 Pain Relevance 0.22
Using splice variant specific primer pairs we were able to detect EP3 subtypes 3, 5, 7 and 8 and to exclude the expression of EP3 subtypes 4 and 6 in HT-29 cells.
Gene_expression (expression) of EP3 in HT-29
12) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.06
Removal of serum leads to the induction of EP3 expression whereas EP3 was virtually undetectable in cells kept in serum.
Gene_expression (undetectable) of EP3
13) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.43 Pain Relevance 0.04
Pharmacological manipulation of EP receptor isoforms confirms a role for EP3/cAMP signalling in PGE2-dependent HT-29 cell proliferation
Gene_expression (cAMP) of EP3 in HT-29
14) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.19
Interestingly, EP3 receptor levels are down regulated in colon cancer mucosa in comparison to healthy tissue [26], indicating that EP3 expression may not be compatible with a high proliferative rate in those cells.
Gene_expression (expression) of EP3 in colon associated with colon cancer
15) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.59 Pain Relevance 0.04
The results of this analysis, shown in Fig. 7A, evidenced that HT-29 cells express EP1, EP2 and EP4 receptors but no EP3.
Gene_expression (receptors) of EP3 in HT-29
16) Confidence 0.43 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.07 Pain Relevance 0.24
Alternative splicing generates three isoforms: EP3 alpha, EP3 beta and EP3 gamma, which differ in the putative cytoplasmic carboxy-terminal tail.
Gene_expression (generates) of EP3 in tail
17) Confidence 0.40 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.50 Pain Relevance 0
Alternative splicing generates three isoforms: EP3 alpha, EP3 beta and EP3 gamma, which differ in the putative cytoplasmic carboxy-terminal tail.
Gene_expression (generates) of EP3 in tail
18) Confidence 0.40 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.50 Pain Relevance 0
Alternative splicing generates three isoforms: EP3 alpha, EP3 beta and EP3 gamma, which differ in the putative cytoplasmic carboxy-terminal tail.
Gene_expression (generates) of EP3 in tail
19) Confidence 0.40 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.50 Pain Relevance 0
As a further control we used total RNA from K562 cells, which expressed EP3 receptor subtypes 2 and 4–8.
Gene_expression (expressed) of EP3
20) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0 Pain Relevance 0.03

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