INT10763

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Context Info
Confidence 0.80
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 157
Total Number 158
Disease Relevance 81.11
Pain Relevance 33.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cells 23
NK cells 8
lymphocytes 7
T-helper cell 6
monocytes 5
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1928 100.00 Very High Very High Very High
Inflammation 1432 100.00 Very High Very High Very High
headache 114 100.00 Very High Very High Very High
Opioid 46 100.00 Very High Very High Very High
intrathecal 5 99.98 Very High Very High Very High
spinal inflammation 70 99.84 Very High Very High Very High
opioid receptor 28 99.80 Very High Very High Very High
noradrenaline 6 99.76 Very High Very High Very High
Multiple sclerosis 118 99.72 Very High Very High Very High
Cluster headache 2 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1853 100.00 Very High Very High Very High
INFLAMMATION 1659 100.00 Very High Very High Very High
Necrosis 93 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1208 99.84 Very High Very High Very High
Infection 437 99.84 Very High Very High Very High
Low Back Pain 88 99.84 Very High Very High Very High
Demyelinating Disease 104 99.72 Very High Very High Very High
Toxicity 98 99.68 Very High Very High Very High
Paralysis 10 99.60 Very High Very High Very High
Cluster Headache 2 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased IL-2 synthesis by PBMCs was not accompanied by a systemic (in vivo) release of IL-2 in response to any of the interventions.
Localization (release) of IL-2
1) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Thus, an increase in the number of IL-2 secreting DCs in the PBMC preparations examined after the intervention, might explain the observed increase in IL-2 production in cultures derived from SMT-C and SMT-NC – treated subjects.
Localization (secreting) of IL-2
2) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.16 Pain Relevance 0
The levels of IL-2 released spontaneously in cultures from the remaining subjects showed no significant alterations over the study period.
Localization (released) of IL-2
3) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
The results of the present study demonstrate clearly that manipulative intervention provided by spinal manipulation of the thoracic spine, results in a significant augmentation of IL-2 secretion in vitro induced by SPA.
Localization (secretion) of IL-2 in spine
4) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0
Similarly, constitutive (spontaneous) in vitro secretion of IL-2 remained consistently comparable in all study groups.
Localization (secretion) of IL-2
5) Confidence 0.80 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.03
In RR there is a sudden enhancement of already existing DTH to M. leprae and its antigens resulting in the release of excessive quantities of TNF alpha, INF gamma, and IL-2.
Localization (release) of IL-2
6) Confidence 0.78 Published 1996 Journal Indian J Lepr Section Abstract Doc Link 8727113 Disease Relevance 0.86 Pain Relevance 0.07
Interleukin-2 (IL-2) is a polypeptide secreted by antigen or mitogen-actuated T lymphocytes that functions as a growth factor for T cells.
Localization (secreted) of IL-2 in T cells
7) Confidence 0.78 Published 1991 Journal Headache Section Abstract Doc Link 1860789 Disease Relevance 0.62 Pain Relevance 0.62
Interleukin-2 (IL-2) is a polypeptide secreted by antigen or mitogen-actuated T lymphocytes that functions as a growth factor for T cells.
Localization (secreted) of Interleukin-2 in T cells
8) Confidence 0.78 Published 1991 Journal Headache Section Abstract Doc Link 1860789 Disease Relevance 0.62 Pain Relevance 0.62
The method used to detect CD4 and CD8 T cell responsiveness by secretion of Interleukin-2 (IL-2) and/or IFN-?
Localization (secretion) of Interleukin-2 in T cell
9) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943475 Disease Relevance 0.39 Pain Relevance 0.04
The immunomodulatory capacity of these compounds was evaluated by determining the interleukin-2 (IL-2) release in mitogen activated PBMC.
Localization (release) of interleukin-2 in PBMC
10) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15102522 Disease Relevance 0.09 Pain Relevance 0.53
The immunomodulatory capacity of these compounds was evaluated by determining the interleukin-2 (IL-2) release in mitogen activated PBMC.
Localization (release) of IL-2 in PBMC
11) Confidence 0.77 Published 2004 Journal Life Sci. Section Abstract Doc Link 15102522 Disease Relevance 0.09 Pain Relevance 0.53
In the PCA patients, IL-2 was decreased in group M and increased in group F postoperatively.
Localization (decreased) of IL-2
12) Confidence 0.75 Published 2006 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 17120754 Disease Relevance 0 Pain Relevance 1.31
They each received up to 8 subcutaneous injections of a vaccine combining lymphotactin--and interleukin-2 (IL-2)--secreting autologous neuroblastoma cells in a dose-escalating scheme.
Localization (secreting) of interleukin-2 associated with neuroblastoma
13) Confidence 0.74 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 0.84 Pain Relevance 0.17
They each received up to 8 subcutaneous injections of a vaccine combining lymphotactin--and interleukin-2 (IL-2)--secreting autologous neuroblastoma cells in a dose-escalating scheme.
Localization (secreting) of IL-2 associated with neuroblastoma
14) Confidence 0.74 Published 2007 Journal J. Immunother. Section Abstract Doc Link 17471169 Disease Relevance 0.84 Pain Relevance 0.17
Phase I trial of vaccination with autologous neuroblastoma tumor cells genetically modified to secrete IL-2 and lymphotactin.
Localization (secrete) of IL-2 associated with neuroblastoma and cancer
15) Confidence 0.74 Published 2007 Journal J. Immunother. Section Title Doc Link 17471169 Disease Relevance 0.86 Pain Relevance 0.17
The T-helper 1 cells, that secrete interleukin-2 and interferon-gamma for example, are reduced in activity while the T-helper 2 cells, together with the macrophages, show an increased secretion of interleukins-6 and -10.
Localization (secrete) of interleukin-2 in macrophages
16) Confidence 0.73 Published 2005 Journal Expert Rev Clin Immunol Section Abstract Doc Link 20477658 Disease Relevance 0.99 Pain Relevance 0.14
T cells were cultured for 4 days in the presence of rIL-2 (1.5ng/ml) and either rIL-12 (8ng/ml) plus anti-IL-4 mAb (10µg/ml) for Th1-polarizing conditions or rIL-4 (20ng/ml) plus anti-IFN?
Localization (presence) of IL-2 in T cells
17) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.03
[Pharmacokinetics and toxicity of intrathecal administration of recombinant interleukin 2].
Localization (administration) of interleukin 2 associated with toxicity and intrathecal
18) Confidence 0.73 Published 1986 Journal Gan To Kagaku Ryoho Section Title Doc Link 3488031 Disease Relevance 0.66 Pain Relevance 0.25
A single HVLA manipulation to the thoracic spine of asymptomatic subjects causes a significant enhancement in IL-2 secretion by PBMCs in vitro.
Localization (secretion) of IL-2 in spine
19) Confidence 0.70 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.06 Pain Relevance 0.06
Compared with VC and their respective baselines, SPA-induced secretion of IL-2 increased significantly in cultures established from both SMT-C and SMT-NC subjects at 20 min post-intervention.
Localization (secretion) of IL-2
20) Confidence 0.70 Published 2008 Journal Chiropr Osteopat Section Abstract Doc Link PMC2423359 Disease Relevance 0 Pain Relevance 0.05

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