INT107641

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.44
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1)
Anatomy Link Frequency
FcRn 1
Th2 cells 1
egg 1
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 188 97.88 Very High Very High Very High
Inflammatory response 10 96.48 Very High Very High Very High
rheumatoid arthritis 147 93.48 High High
Pain 2 92.76 High High
Arthritis 37 89.28 High High
fibrosis 11 86.08 High High
Osteoarthritis 42 81.92 Quite High
tolerance 12 77.68 Quite High
cytokine 212 60.96 Quite High
transdermal 21 50.00 Quite Low
Disease Link Frequency Relevance Heat
Immunization 162 99.98 Very High Very High Very High
Asthma 442 99.48 Very High Very High Very High
Disease 263 99.16 Very High Very High Very High
INFLAMMATION 195 97.88 Very High Very High Very High
Eczema 13 96.24 Very High Very High Very High
Metaplasia 6 95.48 Very High Very High Very High
Systemic Lupus Erythematosus 23 94.80 High High
Eosinophilia 26 94.40 High High
Hypergammaglobulinemia 7 94.28 High High
Hemorrhage 3 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In offspring deficient in FcRn, we expected reduced levels of systemic allergen-specific IgG1, a consequence of decreased absorption of maternal IgG from the lumen of the neonatal gastrointestinal tract.
Negative_regulation (reduced) of IgG1 in FcRn
1) Confidence 0.39 Published 2010 Journal Clin Mol Allergy Section Abstract Doc Link PMC2914046 Disease Relevance 1.12 Pain Relevance 0
They also reported that the two bacteria significantly decrease serum levels of OVA-specific IgE/IgG1 and prevent asthma before and after OVA sensitization, which is not in accordance with our results.
Negative_regulation (decrease) of IgG1 associated with asthma
2) Confidence 0.39 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892053 Disease Relevance 0.68 Pain Relevance 0.08
Thus, along with Zhang and colleagues [4] and Takeda and colleagues [3] we show that a decreased airway responsiveness in C57BL/6 mice is not accompanied by similar reduction in the total and antigen-specific IgE and IgG1 levels.


Negative_regulation (reduction) of IgG1
3) Confidence 0.35 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.33 Pain Relevance 0.07
That is, the decrease of IgG1 titers with in vivo vitamin C treatment was quite remarkable (Fig. 1), in contrast to those observed in in vitro experiments (Fig. 6), which was just slight.
Negative_regulation (decrease) of IgG1
4) Confidence 0.34 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998772 Disease Relevance 0.22 Pain Relevance 0
Two-way ANOVA showed no significant effect of cathepsin D deficiency on IgM, IgG1 or IgG2b (P > 0.05).
Negative_regulation (deficiency) of IgG1
5) Confidence 0.31 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2048983 Disease Relevance 0.27 Pain Relevance 0
production after IM vaccination is consistent with the heightened Th1-like response indicated by the reduced IgG1/IgG2a ratio in the IM groups, since IFN-?
Negative_regulation (reduced) of IgG1
6) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.16 Pain Relevance 0
We found that the IM-immunized groups on day 14 after immunization exhibited IgG1/IgG2a ratios of 2 and 0.3 with 3 µg and 10 µg inactivated virus, respectively (Figure 3B, D).
Negative_regulation (exhibited) of IgG1 associated with immunization
7) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.55 Pain Relevance 0
In contrast, the MN-immunized groups had IgG1/IgG2a ratios of 24 and 4 in the 3 µg and 10 µg groups, respectively.
Negative_regulation (had) of IgG1
8) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.56 Pain Relevance 0
Meanwhile, serum levels of OVA-specific IgG1 and IgG2a tended to decrease in group 1 without any statistical significance, suggesting that Lactobacillus casei rhamnosus Lcr35 may modify immune reactions by both Th1 and Th2 cells rather than by either alone.
Negative_regulation (decrease) of IgG1 in Th2 cells
9) Confidence 0.29 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2892053 Disease Relevance 0.71 Pain Relevance 0.15
The serum IgG1 levels decreased from 1632.9 mg/dl to 681.0 mg/dl (P < 0.005) and those of serum IgG4 decreased from 1556.4mg/dl to 234.7mg/dl (P < 0.005).
Negative_regulation (decreased) of IgG1
10) Confidence 0.27 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2785894 Disease Relevance 1.44 Pain Relevance 0
inhibitors inhibit IgG1 or
Negative_regulation (inhibit) of IgG1
11) Confidence 0.25 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.46 Pain Relevance 0.25
suppressed the IgG1
Negative_regulation (suppressed) of IgG1
12) Confidence 0.25 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2233982 Disease Relevance 0.39 Pain Relevance 0.20
The decrease of pathogenic autoantibodies and switch of subclass toward IgG1 may also be relevant [17].
Negative_regulation (decrease) of IgG1
13) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592775 Disease Relevance 0.65 Pain Relevance 0.15
Allergen-specific IgG1 and IgE serum levels are also strongly reduced.
Negative_regulation (reduced) of IgG1
14) Confidence 0.24 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.07 Pain Relevance 0
The NOELs for suppression of IgE and IgG1 for individual monophthalates were 100 ?
Negative_regulation (suppression) of IgG1
15) Confidence 0.23 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2453150 Disease Relevance 0 Pain Relevance 0.03
There was, however, a significant reduction of IgG1 constant region message in synovial tissues after rituximab treatment (Figure 6b).
Negative_regulation (reduction) of IgG1
16) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.09 Pain Relevance 0
A progressive significant decrease in the level of circulating anti-SWAP IgG1 after treatment, a decrease of IgG4 three months after treatment and a decrease in the egg count after therapy.
Negative_regulation (decrease) of IgG1 in egg
17) Confidence 0.20 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12512825 Disease Relevance 0.51 Pain Relevance 0.15
However, in aggregate-containing tissues, rituximab significantly reduced total IgM and IgG SSI as well as IgM and IgG1 mRNA.
Negative_regulation (reduced) of IgG1
18) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592782 Disease Relevance 0.66 Pain Relevance 0.33
Anti-SWAP IgG1 and IgG4 is useful means in diagnosis and cure, as well as significant reduction of anti-SWAP IgG1 and IgG4 after treatment.
Negative_regulation (reduction) of IgG1
19) Confidence 0.09 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12512825 Disease Relevance 0.43 Pain Relevance 0.13

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