INT107655

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 5.09
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
spinal cord 6
dorsal horn 4
dorsal 2
neurons 2
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 12 100.00 Very High Very High Very High
Glutamate 8 100.00 Very High Very High Very High
Kinase C 6 100.00 Very High Very High Very High
dorsal root ganglion 3 100.00 Very High Very High Very High
amygdala 16 99.12 Very High Very High Very High
antagonist 6 98.16 Very High Very High Very High
Dorsal horn neuron 6 96.64 Very High Very High Very High
Neuropathic pain 18 96.28 Very High Very High Very High
intrathecal 3 94.64 High High
agonist 3 93.60 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 100.00 Very High Very High Very High
Diabetes Mellitus 24 99.84 Very High Very High Very High
Arthritis 9 99.18 Very High Very High Very High
Nociception 9 97.16 Very High Very High Very High
Neuropathic Pain 19 96.28 Very High Very High Very High
Hyperalgesia 4 81.80 Quite High
Pain 6 75.00 Quite High
Diabetic Neuropathy 6 70.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that increased mGluR5 expression on primary afferent neurons contributes to increased glutamatergic input to spinal dorsal horn neurons and nociceptive transmission in diabetic neuropathic pain.
Positive_regulation (increased) of Gene_expression (expression) of mGluR5 in dorsal horn associated with nociception, diabetes mellitus, neuropathic pain and dorsal horn neuron
1) Confidence 0.67 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840219 Disease Relevance 1.15 Pain Relevance 0.58
Expression of mGluR5 receptors increased over pregnancy.
Positive_regulation (increased) of Gene_expression (Expression) of mGluR5
2) Confidence 0.49 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.06 Pain Relevance 0.81
These findings suggest that increased mGluR5 expression on primary afferent neurons contributes to increased glutamatergic input to spinal dorsal horn neurons and nociceptive transmission in diabetic neuropathic pain.
Positive_regulation (increased) of Gene_expression (expression) of mGluR5 in dorsal horn associated with nociception, diabetes mellitus, neuropathic pain and dorsal horn neuron
3) Confidence 0.49 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840219 Disease Relevance 1.15 Pain Relevance 0.58
A selective mGluR1 antagonist reduced transmission in CeA neurons from arthritic animals but not in control neurons, and increased levels of mGluR1 and mGluR5 protein were measured in the CeA of arthritic rats compared with controls.
Positive_regulation (increased) of Gene_expression (levels) of mGluR5 protein in neurons associated with antagonist, amygdala and arthritis
4) Confidence 0.46 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.84 Pain Relevance 1.16
These findings support the idea that the increased levels of mGluR5 in the spinal cord may be, at least in part, involved in the induction of ethanol-dependent neuropathic pain-like state.
Positive_regulation (increased) of Gene_expression (levels) of mGluR5 in spinal cord associated with neuropathic pain and spinal cord
5) Confidence 0.45 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17081689 Disease Relevance 0.39 Pain Relevance 0.54
We previously reported that the levels of metabotropic glutamate 5 (mGlu5) receptor and phosphorylated-protein kinase C (PKC) were significantly increased in the spinal cord following chronic ethanol consumption.
Positive_regulation (increased) of Gene_expression (levels) of mGlu5 in spinal cord associated with kinase c, glutamate and spinal cord
6) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17349994 Disease Relevance 0.41 Pain Relevance 0.64
In the spinal cord, the expressions of mGluR5 mRNA and protein were significantly elevated in the C3 group than in the S3 and the control group (P < 0.05).
Positive_regulation (elevated) of Gene_expression (expressions) of mGluR5 mRNA in spinal cord
7) Confidence 0.35 Published 2007 Journal Zhongguo Yi Xue Ke Xue Yuan Xue Bao Section Body Doc Link 17380680 Disease Relevance 0.06 Pain Relevance 0
The mGluR5 protein level in the dorsal root ganglion, but not in the dorsal spinal cord, was significantly increased in diabetic rats compared with that in control rats.
Positive_regulation (increased) of Gene_expression (level) of mGluR5 protein in dorsal associated with ganglion cysts, dorsal root ganglion, diabetes mellitus and spinal cord
8) Confidence 0.35 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 19840219 Disease Relevance 1.03 Pain Relevance 0.74

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