INT107656

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Context Info
Confidence 0.26
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.84
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
nucleus accumbens 2
spinal cord 2
neurons 2
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 5 100.00 Very High Very High Very High
antagonist 2 100.00 Very High Very High Very High
withdrawal 5 99.76 Very High Very High Very High
amygdala 16 99.68 Very High Very High Very High
Morphine 6 99.10 Very High Very High Very High
Spinal cord 2 98.86 Very High Very High Very High
Glutamate receptor 8 98.34 Very High Very High Very High
Arthritis 3 90.88 High High
Glutamate 14 88.96 High High
Pain 8 87.68 High High
Disease Link Frequency Relevance Heat
Arthritis 9 99.40 Very High Very High Very High
Nociception 1 81.12 Quite High
Pain 5 75.00 Quite High
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A selective mGluR1 antagonist reduced transmission in CeA neurons from arthritic animals but not in control neurons, and increased levels of mGluR1 and mGluR5 protein were measured in the CeA of arthritic rats compared with controls.
Regulation (measured) of Gene_expression (levels) of mGluR5 protein in neurons associated with antagonist, amygdala and arthritis
1) Confidence 0.26 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.84 Pain Relevance 1.14
OBJECTIVE: To investigate the expression of metabotropic glutamate receptor 5 (mGluRS) in spinal cord of morphine tolerant rats and understand the influence of mGluR5 antagonist MPEP upon the expression of mGluRS.
Regulation (influence) of Gene_expression (expression) of mGluRS in spinal cord associated with antagonist, glutamate receptor, morphine and spinal cord
2) Confidence 0.24 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 20058604 Disease Relevance 0 Pain Relevance 0.40
Receptor density was evaluated after chronic treatment and after 1, 3, and 14 days of withdrawal. mGlu1 and mGlu5 expression in the nucleus accumbens and in the caudate putamen was not affected by any of the experimental manipulations.
Neg (not) Regulation (affected) of Gene_expression (expression) of mGlu5 in nucleus accumbens associated with nucleus accumbens and withdrawal
3) Confidence 0.21 Published 2008 Journal Neuroreport Section Abstract Doc Link 18520992 Disease Relevance 0 Pain Relevance 0.85
To test whether Siah1a expression altered the surface expression of group I mGluRs, the surface distribution of mGluR5a-myc was examined in the absence and presence of Siah1a.
Spec (whether) Regulation (altered) of Gene_expression (expression) of mGluRs
4) Confidence 0.01 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC58838 Disease Relevance 0 Pain Relevance 0

General Comments

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