INT107657

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.83
Pain Relevance 8.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
spinal 2
juvenile 2
neurons 2
CeA 2
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 17 100.00 Very High Very High Very High
medulla 14 100.00 Very High Very High Very High
antinociception 18 99.92 Very High Very High Very High
long-term potentiation 5 99.84 Very High Very High Very High
amygdala 16 99.60 Very High Very High Very High
Morphine 33 99.32 Very High Very High Very High
tolerance 15 98.92 Very High Very High Very High
depression 3 98.52 Very High Very High Very High
nMDA receptor 10 98.38 Very High Very High Very High
antagonist 16 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 4 99.64 Very High Very High Very High
Depression 3 98.52 Very High Very High Very High
Arthritis 9 94.84 High High
Injury 3 89.80 High High
Nociception 10 89.44 High High
Ganglion Cysts 2 87.96 High High
Pain 11 75.00 Quite High
Myelodysplastic Syndromes 2 5.00 Very Low Very Low Very Low
Ketoacidosis 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the activation of NMDA receptor after chronic morphine administration has been verified, we suppose there is an enhanced activation of mGluR5 during the development of tolerance to morphine-induced antinociception.
Positive_regulation (enhanced) of Positive_regulation (activation) of mGluR5 associated with antinociception, nmda receptor, tolerance and morphine
1) Confidence 0.69 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17512115 Disease Relevance 0 Pain Relevance 1.99
These results demonstrate that the activation of mGluR5 and in turn triggering a PLC/PKC-dependent signaling cascade may contribute to the induction of LTP of primary afferent synaptic transmission in the superficial layer of trigeminal caudal nucleus of juvenile rats.
Positive_regulation (induction) of Positive_regulation (activation) of mGluR5 in juvenile associated with kinase c and long-term potentiation
2) Confidence 0.50 Published 2005 Journal Pain Section Abstract Doc Link 15777867 Disease Relevance 0.10 Pain Relevance 0.80
Activation of mGluR5 may mobilize the release of intracellular Ca(2+) and activate PKC, leading to morphine-induced antinociception suppression.
Spec (may) Positive_regulation (mobilize) of Positive_regulation (Activation) of mGluR5 associated with antinociception and morphine
3) Confidence 0.50 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17512115 Disease Relevance 0 Pain Relevance 1.99
Activation of mGluR5 may mobilize the release of intracellular Ca(2+) and activate PKC, leading to morphine-induced antinociception suppression.
Positive_regulation (activate) of Positive_regulation (Activation) of mGluR5 associated with antinociception and morphine
4) Confidence 0.50 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17512115 Disease Relevance 0 Pain Relevance 2.01
Synaptic plasticity in the CeA was accompanied by increased presynaptic mGluR1 function and upregulation of mGluR1 and mGluR5.
Positive_regulation (increased) of Positive_regulation (upregulation) of mGluR5 in CeA associated with amygdala
5) Confidence 0.49 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12514201 Disease Relevance 0.99 Pain Relevance 1.34
Therefore, the DHPG-induced increase of sEPSC frequency, found in the present study, is probably originated from the activation of both mGluR1 and mGluR5 at terminals of other brainstem neurons or local Vo neurons, as well as the activation of mGluR5 at trigeminal afferent terminals in Vo [36].
Positive_regulation (activation) of Positive_regulation (activation) of mGluR5 in neurons associated with medulla
6) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2743647 Disease Relevance 0.09 Pain Relevance 0.19
I.t. injection of MPEP before i.t. injection of DHPG blocked DHPG-evoked cold hypersensitivity, suggesting that activation of spinal mGlu5 receptors induces this behavioral response.
Positive_regulation (induces) of Positive_regulation (activation) of mGlu5 in spinal associated with hypersensitivity
7) Confidence 0.22 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12646279 Disease Relevance 0.66 Pain Relevance 0.59

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox