INT10769

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Context Info
Confidence 0.10
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.39
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR3C2) signal transduction (NR3C2) endoplasmic reticulum (NR3C2)
nucleus (NR3C2) cytoplasm (NR3C2)
NR3C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 98.72 Very High Very High Very High
Opioid 1 75.00 Quite High
Inflammation 15 5.00 Very Low Very Low Very Low
spastic colon 9 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 48 92.76 High High
Inflammatory Bowel Disease 63 68.80 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 45.00 Quite Low
Functional Bowel Disorder 12 23.52 Low Low
Gastrointestinal Disease 12 5.00 Very Low Very Low Very Low
Colon Cancer 6 5.00 Very Low Very Low Very Low
Diverticulitis 3 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low
Constipation 3 5.00 Very Low Very Low Very Low
Pneumatosis Cystoides Intestinalis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several mismatches to the mrtA gene sequence of Msp.stadtmanae were evident with the mcrA primer set and phylogenetic analysis and tree construction illustrates that although the mrtA gene of Msp. stadtmanae encodes an enzyme of the same function and inhabits the same niche it is phylogenetically distinct from mcrA gene sequences of Mbb. smithii and related clones (see Figure 2).
Positive_regulation (sequences) of mcrA
1) Confidence 0.10 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.24 Pain Relevance 0
Four randomly selected individuals per group that gave a positive PCR result for mcrA gene amplification were chosen to generate mcrA gene clone libraries.
Positive_regulation (result) of mcrA
2) Confidence 0.10 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.09 Pain Relevance 0
All experiments were conducted in duplicate and PCR for mcrA gene amplification was conduced on each extract as previously outlined.
Positive_regulation (conduced) of mcrA
3) Confidence 0.10 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.05 Pain Relevance 0
This observation is in agreement with our model proposed for the cyclic enkephalin analogues: folded forms with close aromatic ring placement are required for the activity at the delta-receptor.
Positive_regulation (required) of delta-receptor associated with enkephalin
4) Confidence 0.08 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1517015 Disease Relevance 0 Pain Relevance 0.24

General Comments

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