INT107714

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.88
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PPARG) enzyme binding (PPARG) DNA binding (PPARG)
lipid metabolic process (PPARG) cytoplasm (PPARG) cytosol (PPARG)
Anatomy Link Frequency
adipose tissue 1
PPARG (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 79 95.44 Very High Very High Very High
dexamethasone 1 88.08 High High
Central nervous system 1 83.68 Quite High
cINOD 10 79.92 Quite High
Inflammation 5 70.68 Quite High
Hippocampus 1 68.16 Quite High
agonist 9 64.56 Quite High
COX-2 inhibitor 1 56.12 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 100.00 Very High Very High Very High
Obesity 5 99.04 Very High Very High Very High
Colon Cancer 4 93.04 High High
Metabolic Disorder 2 83.92 Quite High
Alzheimer's Dementia 1 82.72 Quite High
INFLAMMATION 8 75.00 Quite High
Disease 8 68.80 Quite High
Skin Cancer 59 64.76 Quite High
Aging 2 41.68 Quite Low
Cancer 47 32.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We present a novel class of dual modulators of gamma-secretase and peroxisome proliferator-activated receptor gamma (PPARgamma) based on the structure of 2-(bis(phenethoxy)pyrimidine-2-ylthio)hexanoic acid 8 (IC(50)(Abeta42) = 22.8 microM, EC(50)(PPARgamma) = 8.3 microM).
Localization (gamma-secretase) of peroxisome proliferator-activated receptor gamma
1) Confidence 0.73 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20503989 Disease Relevance 0.15 Pain Relevance 0.21
g/mL), anti-PPARG (rabbit monoclonal, Cell Signalling, New England Biolabs GmbH, Frankfurt am Main, Germany; dilution 1 : 400), anti-TP53 (mouse monoclonal IgG, clone Bp53-12 (sc-263), Santa Cruz Biotechnology Santa Cruz, Calif, USA; dilution 1 : 1000), and anti-Ki-67 (rabbit monoclonal, clone MIB1; DakoCytomation GmbH, Hamburg, Germany; dilution 1 : 10, final concentration 5 ?
Localization (dilution) of PPARG
2) Confidence 0.70 Published 2010 Journal PPAR Research Section Body Doc Link PMC2712952 Disease Relevance 0.23 Pain Relevance 0.27
Unlike IL-1beta, NS-398 and Cig did not cause NF-kappaB (p65) nuclear translocation, nor did they further enhance IL-1beta-induced NF-kappaB translocation, but they stimulated PPARgamma translocation.
Localization (translocation) of PPARgamma
3) Confidence 0.68 Published 2003 Journal J. Immunol. Section Abstract Doc Link 12517972 Disease Relevance 0.07 Pain Relevance 0.36
In the adipose tissue, Sirt1 triggers fat mobilization by inhibiting peroxisome proliferator-activated receptor (PPAR-gamma), and in the pancreas repression of the uncoupling protein 2 (UCP2) by Sirt1 increases insulin secretion [1].
Localization (secretion) of peroxisome proliferator-activated receptor in adipose tissue associated with repression and obesity
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.43 Pain Relevance 0.08

General Comments

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