INT107723

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.71
Pain Relevance 2.82

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small molecule metabolic process (POMC) signal transducer activity (MC1R) cell-cell signaling (POMC)
cytoplasm (POMC) pigmentation (MC1R) extracellular space (POMC)
Anatomy Link Frequency
melanocyte 7
POMC (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 34 100.00 Very High Very High Very High
agonist 5 72.08 Quite High
antagonist 1 50.32 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 18 75.00 Quite High
Microphthalmia 2 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alpha-melanocyte-stimulating hormone (alpha-MSH) activates the melanocortin-1 receptor (MC1R) on melanocytes to promote a switch from red/yellow pheomelanin synthesis to darker eumelanins via positive coupling to adenylate cyclase.
alpha-MSH Positive_regulation (activates) of MC1R in melanocyte associated with melanocortin 1 receptor
1) Confidence 0.68 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.07 Pain Relevance 0.39
Alpha-melanocyte-stimulating hormone (alpha-MSH) activates the melanocortin-1 receptor (MC1R) on melanocytes to promote a switch from red/yellow pheomelanin synthesis to darker eumelanins via positive coupling to adenylate cyclase.
Alpha-melanocyte-stimulating hormone Positive_regulation (activates) of melanocortin-1 receptor in melanocyte associated with melanocortin 1 receptor
2) Confidence 0.68 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.07 Pain Relevance 0.39
Alpha-melanocyte-stimulating hormone (alpha-MSH) activates the melanocortin-1 receptor (MC1R) on melanocytes to promote a switch from red/yellow pheomelanin synthesis to darker eumelanins via positive coupling to adenylate cyclase.
alpha-MSH Positive_regulation (activates) of melanocortin-1 receptor in melanocyte associated with melanocortin 1 receptor
3) Confidence 0.68 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.07 Pain Relevance 0.39
Alpha-melanocyte-stimulating hormone (alpha-MSH) activates the melanocortin-1 receptor (MC1R) on melanocytes to promote a switch from red/yellow pheomelanin synthesis to darker eumelanins via positive coupling to adenylate cyclase.
Alpha-melanocyte-stimulating hormone Positive_regulation (activates) of MC1R in melanocyte associated with melanocortin 1 receptor
4) Confidence 0.68 Published 2005 Journal Peptides Section Abstract Doc Link 15992961 Disease Relevance 0.07 Pain Relevance 0.39
Production of the pigment eumelanin is controlled by alpha-melanocyte stimulating hormone (alpha-MSH) stimulation of melanocortin 1 receptor (Mc1r), whereas production of pheomelanin results from agouti antagonism of alpha-MSH signalling through Mc1r.
alpha-MSH Positive_regulation (stimulation) of melanocortin 1 receptor in melanocyte associated with melanocortin 1 receptor
5) Confidence 0.27 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12519127 Disease Relevance 0.20 Pain Relevance 0.30
Production of the pigment eumelanin is controlled by alpha-melanocyte stimulating hormone (alpha-MSH) stimulation of melanocortin 1 receptor (Mc1r), whereas production of pheomelanin results from agouti antagonism of alpha-MSH signalling through Mc1r.
alpha-MSH Positive_regulation (stimulation) of Mc1r in melanocyte associated with melanocortin 1 receptor
6) Confidence 0.27 Published 2003 Journal Pigment Cell Res. Section Abstract Doc Link 12519127 Disease Relevance 0.20 Pain Relevance 0.30
Activation of MC1R by adrenocorticotrophin or alpha-melanocyte stimulating hormone is positively coupled to the cAMP signaling pathway and leads to a stimulation of melanogenesis and a switch from the synthesis of pheomelanins to the production of eumelanic pigments.
stimulating hormone Positive_regulation (Activation) of MC1R in melanocyte associated with melanocortin 1 receptor
7) Confidence 0.01 Published 2005 Journal Pigment Cell Res. Section Abstract Doc Link 16280005 Disease Relevance 0 Pain Relevance 0.67

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