INT107732

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pld2) plasma membrane (Pld2) nucleus (Pld2)
Pld2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 10 99.56 Very High Very High Very High
Morphine 4 96.08 Very High Very High Very High
opioid receptor 10 94.88 High High
Kinase C 6 89.36 High High
Enkephalin 2 89.28 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coimmunoprecipitation experiments in HEK293 cells coexpressing MOR1 and PLD2 confirmed that MOR1 constitutively interacts with PLD2.
Gene_expression (coexpressing) of PLD2
1) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.50
Conversely the inhibition of PLD2-mediated phosphatidic acid formation by 1-butanol or overexpression of a negative mutant of PLD2 prevented agonist-mediated endocytosis of MOR1.
Gene_expression (overexpression) of PLD2 associated with agonist
2) Confidence 0.75 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.74

General Comments

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