INT107735

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Pld2) plasma membrane (Pld2) nucleus (Pld2)
Pld2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 99.98 Very High Very High Very High
Enkephalin 2 99.96 Very High Very High Very High
agonist 13 99.80 Very High Very High Very High
Morphine 4 99.24 Very High Very High Very High
opioid receptor 20 99.04 Very High Very High Very High
tolerance 1 94.08 High High
Kinase C 6 80.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis.
Positive_regulation (required) of Positive_regulation (activation) of phospholipase D2 associated with agonist and opioid receptor
1) Confidence 0.48 Published 2003 Journal J. Biol. Chem. Section Title Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.47
Treatment with the mu receptor agonist DAMGO ([d-Ala(2), Me Phe(4), Glyol(5)]enkephalin) led to an increase in PLD2 activity, whereas morphine, which does not induce MOR1 receptor internalization, failed to induce PLD2 activation.
Positive_regulation (led) of Positive_regulation (increase) of PLD2 associated with agonist, enkephalin and morphine
2) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.64
We demonstrated recently that opioid-induced activation of phospholipase D2 (PLD2) enhances mu- (MOPr) and delta-opioid receptor endocytosis/recycling and thus reduces the development of opioid receptor desensitization and tolerance.
Positive_regulation (induced) of Positive_regulation (activation) of phospholipase D2 associated with tolerance, opioid receptor and opioid
3) Confidence 0.04 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20354103 Disease Relevance 0 Pain Relevance 0.36

General Comments

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