INT107738

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 1.93

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Golgi apparatus (Pld2) plasma membrane (Pld2) nucleus (Pld2)
signal transducer activity (Oprm1)
Anatomy Link Frequency
vesicles 4
Pld2 (Rattus norvegicus)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 25 100.00 Very High Very High Very High
agonist 25 97.36 Very High Very High Very High
Enkephalin 5 93.68 High High
Morphine 10 89.12 High High
Kinase C 15 71.28 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a yeast two-hybrid screen, the rat mu-opioid receptor (MOR1, also termed MOP) was found to be associated with phospholipase D2 (PLD2), a phospholipid-specific phosphodiesterase located in the plasma membrane, which has been implicated in the formation of endocytotic vesicles.
PLD2 Binding (associated) of MOR1 in vesicles associated with opioid receptor
1) Confidence 0.23 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.35
Using a yeast two-hybrid screen, the rat mu-opioid receptor (MOR1, also termed MOP) was found to be associated with phospholipase D2 (PLD2), a phospholipid-specific phosphodiesterase located in the plasma membrane, which has been implicated in the formation of endocytotic vesicles.
phospholipase D2 Binding (associated) of MOR1 in vesicles associated with opioid receptor
2) Confidence 0.23 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.34
Coimmunoprecipitation experiments in HEK293 cells coexpressing MOR1 and PLD2 confirmed that MOR1 constitutively interacts with PLD2.
PLD2 Binding (interacts) of MOR1
3) Confidence 0.23 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.55
Using a yeast two-hybrid screen, the rat mu-opioid receptor (MOR1, also termed MOP) was found to be associated with phospholipase D2 (PLD2), a phospholipid-specific phosphodiesterase located in the plasma membrane, which has been implicated in the formation of endocytotic vesicles.
phospholipase D2 Binding (associated) of mu-opioid receptor in vesicles associated with opioid receptor
4) Confidence 0.20 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.34
Using a yeast two-hybrid screen, the rat mu-opioid receptor (MOR1, also termed MOP) was found to be associated with phospholipase D2 (PLD2), a phospholipid-specific phosphodiesterase located in the plasma membrane, which has been implicated in the formation of endocytotic vesicles.
PLD2 Binding (associated) of mu-opioid receptor in vesicles associated with opioid receptor
5) Confidence 0.20 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.35

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