INT107739

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Prkcg, Pld2) nucleus (Prkcg, Pld2) cytosol (Prkcg)
Golgi apparatus (Pld2) intracellular (Prkcg) response to stress (Prkcg)
Prkcg (Rattus norvegicus)
Pld2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 3 100.00 Very High Very High Very High
opioid receptor 5 98.36 Very High Very High Very High
Morphine 2 95.68 Very High Very High Very High
Enkephalin 1 93.48 High High
agonist 5 91.52 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The DAMGO-mediated PLD2 activation was inhibited by brefeldin A, an inhibitor of ADP-ribosylation factor (ARF) but not by the protein kinase C (PKC) inhibitor calphostin C indicating that opioid receptor-mediated activation of PLD2 is ARF- but not PKC-dependent.
PKC Negative_regulation (inhibited) of Positive_regulation (activation) of PLD2 associated with kinase c and opioid receptor
1) Confidence 0.46 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.79

General Comments

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