INT107751

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC, HSD17B1) cytoplasm (POMC, HSD17B1) cell-cell signaling (POMC)
cytosol (HSD17B1) extracellular space (POMC) generation of precursor metabolites and energy (POMC)
Anatomy Link Frequency
sympathetic 1
POMC (Homo sapiens)
HSD17B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 95.36 Very High Very High Very High
Clonidine 2 93.28 High High
agonist 2 88.92 High High
Disease Link Frequency Relevance Heat
Obesity 8 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, ACTH down-regulated 11 beta-HSD-1 activity with maximal effect at 10(-9) M (65 +/- 20%; P < 0.05) and reduced medium glycerol.
ACTH Negative_regulation (down-regulated) of beta-HSD-1
1) Confidence 0.33 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.22 Pain Relevance 0.10
We conclude that possible distinct hypothalamic mediators regulating adipose tissue 11 beta-HSD-1 might include down-regulation of 11 beta-HSD-1 activity by CRH, ACTH, and alpha 2 sympathetic stimulation, and up-regulation of the enzyme by beta 2 sympathetic stimulation and by the cytokines TNFalpha and IL-1 beta.
ACTH Spec (might) Negative_regulation (down-regulation) of beta-HSD-1 in sympathetic associated with obesity and cytokine
2) Confidence 0.24 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.17 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox