INT107754

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Context Info
Confidence 0.46
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.68
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HSD17B1) small molecule metabolic process (HSD17B1) oxidoreductase activity (HSD17B1)
cytoplasm (HSD17B1)
Anatomy Link Frequency
sympathetic 1
adipocytes 1
sympathetic nervous system 1
HSD17B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 96.24 Very High Very High Very High
Clonidine 3 95.44 Very High Very High Very High
agonist 3 91.08 High High
Disease Link Frequency Relevance Heat
Obesity 12 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that possible distinct hypothalamic mediators regulating adipose tissue 11 beta-HSD-1 might include down-regulation of 11 beta-HSD-1 activity by CRH, ACTH, and alpha 2 sympathetic stimulation, and up-regulation of the enzyme by beta 2 sympathetic stimulation and by the cytokines TNFalpha and IL-1 beta.
Spec (possible) Regulation (regulating) of beta-HSD-1 in sympathetic associated with obesity and cytokine
1) Confidence 0.46 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.17 Pain Relevance 0.23
In this in vitro study, we tested the hypothesis that adipose 11 beta-HSD-1 is regulated by the hypothalamus via circulating hormones, sympathetic nervous system innervation, and/or cytokines.
Regulation (regulated) of beta-HSD-1 in sympathetic nervous system associated with cytokine
2) Confidence 0.46 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.25 Pain Relevance 0.05
Modulation of 11 beta-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers.
Regulation (Modulation) of beta-hydroxysteroid dehydrogenase type 1 in adipocytes associated with obesity
3) Confidence 0.46 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 12519881 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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