INT107755

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.71
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HSD17B1) small molecule metabolic process (HSD17B1) oxidoreductase activity (HSD17B1)
cytoplasm (HSD17B1)
HSD17B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 99.98 Very High Very High Very High
agonist 3 99.74 Very High Very High Very High
Clonidine 3 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 12 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a previous study, we noted that patients with hypothalamic obesity had an increased ratio of cortisol/cortisone metabolites, suggesting enhanced 11 beta-HSD-1 activity.
Positive_regulation (enhanced) of beta-HSD-1 associated with obesity
1) Confidence 0.52 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.25 Pain Relevance 0.04
TNF alpha up-regulated 11 beta-HSD-1 activity maximally at 0.6 x 10(-9) M (140 +/- 20%; P < 0.001); the same cytokine increased 11 beta-HSD-1 mRNA levels to 3-fold of control (P < 0.05) and increased medium glycerol levels to 165 +/- 14% of control (P < 0.01).
Positive_regulation (increased) of beta-HSD-1 associated with cytokine
2) Confidence 0.52 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.25 Pain Relevance 0.18
Of the adrenergic agonists, salbutamol up-regulated 11 beta-HSD-1 activity maximally at 10(-7) M (162 +/- 46%; P < 0.02), and clonidine down-regulated it at 10(-7) M (82 +/- 15%; P < 0.005).
Positive_regulation (up-regulated) of beta-HSD-1 associated with agonist and clonidine
3) Confidence 0.35 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 12519881 Disease Relevance 0.21 Pain Relevance 0.22

General Comments

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