INT107779

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.99
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F7) extracellular space (F7) extracellular region (F7)
plasma membrane (F7)
Anatomy Link Frequency
liver 1
F7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.24 Very High Very High Very High
Inflammation 36 46.28 Quite Low
Bioavailability 19 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coagulation Disorder 2 96.24 Very High Very High Very High
Cirrhosis 7 94.20 High High
Congenital Anomalies 2 93.92 High High
Hemostatic Disorders 1 93.44 High High
Coronary Artery Disease 2 92.56 High High
Burns 64 90.24 High High
Injury 59 90.04 High High
Liver Disease 60 89.08 High High
Arrhythmias 2 Under Development 1 79.24 Quite High
Adhesions 4 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Factor VII activity decreased from 29.4% before acetaminophen therapy to 15.5% when his INR was 6.4, and factor X activity fell from 27.0% to 20.2%.
Negative_regulation (decreased) of Factor VII associated with paracetamol
1) Confidence 0.30 Published 2003 Journal Pharmacotherapy Section Abstract Doc Link 12523469 Disease Relevance 0.08 Pain Relevance 0.66
The liver produces most of the factors involved in coagulation and fibrinolysis that helps maintain the balance between thrombin deposition and removal.38 Patients with cirrhosis frequently experience hemostatic disorders caused by abnormalities of platelet number and/or function, increased fibrinolysis, and deficient synthesis of clotting factors.38 Clotting factor deficiencies develop with the loss of functioning liver paranchymal cells, with early deficits in the Vitamin KĀ–dependent factors (II, VII, IX, X, protein S, and protein C).38 The loss of factor VII significantly interferes with the function of the extrinsic coagulation cascade.38 Hemorrhagic complication is a major concern in patients with cirrhosis undergoing surgical interventions39 and must be considered when preparing a patient with burn injury with preexisting liver disease for surgery.
Negative_regulation (loss) of factor VII in liver associated with liver disease, coagulation disorder, cirrhosis, burns, congenital anomalies, injury and hemostatic disorders
2) Confidence 0.05 Published 2007 Journal J Burns Wounds Section Body Doc Link PMC1892842 Disease Relevance 1.83 Pain Relevance 0
Virgin olive oil containing a high content (400 mg/kg) of phenolic compounds has been demonstrated to also decrease plasminogen activator inhibitor-1 (PAI-1) and factor VII (FVII).
Negative_regulation (decrease) of factor VII
3) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.52 Pain Relevance 0
Virgin olive oil containing a high content (400 mg/kg) of phenolic compounds has been demonstrated to also decrease plasminogen activator inhibitor-1 (PAI-1) and factor VII (FVII).
Negative_regulation (decrease) of FVII
4) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852848 Disease Relevance 0.57 Pain Relevance 0

General Comments

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