INT107801

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 8
Disease Relevance 1.00
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl) endoplasmic reticulum (Ugt1a5)
Anatomy Link Frequency
brain 4
blood 2
Ugt1a5 (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 19 99.64 Very High Very High Very High
Opioid 28 97.98 Very High Very High Very High
antagonist 12 96.84 Very High Very High Very High
narcan 21 96.56 Very High Very High Very High
Neurotransmitter 6 83.36 Quite High
Disease Link Frequency Relevance Heat
Body Weight 17 93.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study indicates that GE-B5 stimulates PRL secretion after peripheral administration and that its action is mediated via classical opioid receptors; moreover, it identifies the minimum peptide dose which must reach the blood in order to exert its action on PRL secretion.
GE-B5 Positive_regulation (stimulates) of Localization (secretion) of PRL in blood associated with opioid receptor
1) Confidence 0.76 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12526862 Disease Relevance 0.18 Pain Relevance 0.32
GE-B5 stimulated PRL secretion; the effect was statistically significant at time 20.
GE-B5 Positive_regulation (stimulated) of Localization (secretion) of PRL
2) Confidence 0.59 Published 2005 Journal Life Sci. Section Abstract Doc Link 15698850 Disease Relevance 0.19 Pain Relevance 0.63
Our experiment indicates that GE-B5 stimulates PRL secretion through opioid receptors located outside the BBB.
GE-B5 Positive_regulation (stimulates) of Localization (secretion) of PRL associated with opioid receptor
3) Confidence 0.59 Published 2005 Journal Life Sci. Section Abstract Doc Link 15698850 Disease Relevance 0.17 Pain Relevance 0.62
We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone.
GE-B5 Positive_regulation (stimulates) of Localization (secretion) of PRL associated with antagonist, narcan and opioid receptor
4) Confidence 0.59 Published 2005 Journal Life Sci. Section Abstract Doc Link 15698850 Disease Relevance 0 Pain Relevance 0.52
Gluten exorphin B5 stimulates prolactin secretion through opioid receptors located outside the blood-brain barrier.
B5 Positive_regulation (stimulates) of Localization (secretion) of prolactin in brain associated with opioid receptor
5) Confidence 0.52 Published 2005 Journal Life Sci. Section Title Doc Link 15698850 Disease Relevance 0.12 Pain Relevance 0.54
We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone.
GE-B5 Positive_regulation (stimulates) of Localization (secretion) of prolactin associated with antagonist, narcan and opioid receptor
6) Confidence 0.43 Published 2005 Journal Life Sci. Section Abstract Doc Link 15698850 Disease Relevance 0 Pain Relevance 0.52
However, since the structure of naloxone allows it to cross the blood-brain barrier (BBB) and antagonize opioid effects centrally as well as peripherally, it could not established, on the basis of those data, if GE-B5-induced PRL release is exerted through sites located inside or outside the BBB.
GE-B5 Positive_regulation (induced) of Localization (release) of PRL in brain associated with narcan and opioid
7) Confidence 0.35 Published 2005 Journal Life Sci. Section Abstract Doc Link 15698850 Disease Relevance 0.14 Pain Relevance 0.57
It has been shown that Gluten Exorphin B5 (Tyr-Gly-Gly-Trp-Leu) stimulates Prolactin secretion in male rats.
B5 Positive_regulation (stimulates) of Localization (secretion) of Prolactin
8) Confidence 0.34 Published 2004 Journal Nutr Neurosci Section Abstract Doc Link 15085559 Disease Relevance 0.20 Pain Relevance 0.17

General Comments

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